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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >EEG coherence adjusted for inter-electrode distance in children with attention-deficit/hyperactivity disorder.
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EEG coherence adjusted for inter-electrode distance in children with attention-deficit/hyperactivity disorder.

机译：注意缺陷/多动障碍儿童的电极间距离调整脑电图相关性。

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摘要

Cognition and behaviour depend on the integration of activity in different brain regions, and hence study of the coupling between regions is useful in understanding dysfunctional processes involved in disorders such as attention-deficit/hyperactivity disorder (AD/HD). Such coupling can be estimated by the electroencephalographic (EEG) coherence between scalp electrodes. However, EEG coherence between two points is strongly affected by the distance between them, being inflated by volume conduction effects at short distances and reduced by signal phase differences at larger distances. These distance effects preclude simple comparison of coherence estimates involving different inter-electrode distances. Our group recently introduced a procedure for adjusting coherence measures to remove such distance effects, and explored its potential using normal children. In this study we applied that coherence adjustment procedure to groups of children with AD/HD of the combined (AD/HDcom) and predominantly inattentive (AD/HDin) subtypes, and compared them with a control group. All groups were age- and gender-matched. AD/HD children were found to have a reciprocal pattern of coherence disturbance in the cortico-cortical circuits involved in slow and fast wave activity-elevated slow-wave coherences and reduced fast-wave coherences. This disturbance was larger for inter-hemispheric than intra-hemispheric coherences, and varied markedly with region, suggesting a complex pattern of coherence anomalies with a substantial frontal focus. This complex pattern differed little between subtypes, suggesting that it may constitute the fundamental dysfunction underlying the inattention common to both groups. In contrast, coherence was globally elevated in children with AD/HDcom compared with both AD/HDin and control children. This elevation in coherence may be directly related to the hyperactivity and impulsivity unique to that subtype. Further research using the coherence adjustment procedure appears useful in elucidating the electrophysiological anomalies underlying AD/HD and other disorders.
机译：认知和行为取决于不同大脑区域活动的整合，因此研究区域之间的耦合有助于理解与注意力缺陷/多动症（AD / HD）等疾病有关的功能障碍过程。可以通过头皮电极之间的脑电图（EEG）相干性来估计这种耦合。但是，两点之间的EEG相干性受两点之间的距离的强烈影响，在短距离时会因体积传导效应而膨胀，而在较大距离时会因信号相位差而降低。这些距离效应妨碍了涉及不同电极间距离的相干估计的简单比较。我们的小组最近介绍了一种调整连贯性措施以消除这种距离影响的程序，并探讨了使用正常儿童的潜力。在这项研究中，我们将一致性调整程序应用于合并（AD / HDcom）和主要是注意力不集中（AD / HDin）亚型的AD / HD儿童组，并将其与对照组进行比较。所有组的年龄和性别均匹配。发现AD / HD儿童在涉及慢波和快波活动性升高的慢波相干性和减少的快速波相干性的皮质-皮质回路中具有相干扰动的倒数模式。半球间的相干性比半球内的相干性更大，并且随着区域的变化而显着变化，表明相干异常的复杂模式具有相当大的正面焦点。这种复杂的模式在亚型之间几乎没有什么不同，表明它可能构成导致两组共同注意力不集中的根本功能障碍。相比之下，与AD / HDin和对照组儿童相比，AD / HDcom患儿的整体一致性整体提高。这种连贯性的提高可能与该亚型独有的多动和冲动直接相关。使用相干调整程序进行的进一步研究似乎有助于阐明AD / HD和其他疾病的电生理异常。

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