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首页> 外文期刊>British journal of neurosurgery >The effect of flurbiprofen on the development of anencephaly in early stage chicken embryos
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The effect of flurbiprofen on the development of anencephaly in early stage chicken embryos

机译：氟比洛芬对早期鸡胚无脑发育的影响

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Objective. The study investigated the effect of flu rbiprofen on the development of anencephaly in early stage chicken embryos. Material and methods. We looked at four groups with a total of 36 embryos. There was a control group, a normal saline group, a normal-dose group and a high-dose group with ten, ten, eight and eight eggs with embryo respectively. Results. Two embryos in the control group, studied with light microscopy at 48 h, were consistent with 28-29 hours' incubation in the Hamburger-Hamilton System. They had open neural tubes. The other embryos in this group were considered normal. One embryo in the normal saline group was on the occlusion stage at 48 h. One embryo showed an open neural tube. They were compatible with 28-29 hours' incubation in the Hamburger-Hamilton system. The remaining eight embryos showed normal development. In the normal dose group, one embryo showed underdevelopment of the embryonic disc and the embryo was dead. In four embryos, the neural tubes were open. One cranial malformation was found that was complicated with anencephaly in one embryo. In two embryos the neural tubes were closed, as they showed normal development, and they reached their expected stages according to the Hamburger-Hamilton classification. There was no malformation or growth retardation. Four experimental embryos were anencephalic in the high dose group, and three embryos had open neural tubes. One embryo exhibited both anencephaly and a neural tube closure defect. None of the embryos in this group showed normal development. Conclusions. Even the usual therapeutic doses of flurbiprofen increased the risk of neural tube defect. Flurbiprofen was found to significantly increase the risk of anencephaly. The provision of improved technical materials and studies with larger sample sizes will reveal the stage of morphological disruption during the development of embryos.
机译：目的。该研究调查了氟比洛芬对早期鸡胚无脑发育的影响。材料与方法。我们研究了四组，共36个胚胎。有一个对照组，一个生理盐水组，一个正常剂量组和一个高剂量组，分别有十个，十个，八个和八个卵有胚胎。结果。对照组的两个胚胎在48 h进行光学显微镜研究，与在Hamburger-Hamilton系统中孵育28-29小时相一致。他们有开放的神经管。该组中的其他胚胎被认为是正常的。生理盐水组中的一个胚胎在48小时处于闭塞阶段。一个胚胎显示出一个开放的神经管。它们与在Hamburger-Hamilton系统中孵化28-29小时兼容。其余八个胚显示正常发育。在正常剂量组中，一个胚显示出胚盘发育不足，并且胚已经死亡。在四个胚胎中，神经管是开放的。发现一个颅骨畸形，在一个胚胎中伴有无脑。在两个胚胎中，由于显示正常发育，神经管已闭合，并且根据汉堡-汉密尔顿分类，它们达到了预期的阶段。没有畸形或生长迟缓。高剂量组中有四个实验胚胎为无脑，而三个胚胎具有开放的神经管。一个胚胎表现出无脑和神经管闭合缺陷。该组中没有一个胚胎显示正常发育。结论甚至常规治疗剂量的氟比洛芬也增加了神经管缺损的风险。发现氟比洛芬显着增加无脑风险。提供改良的技术材料和更大样本量的研究将揭示胚胎发育过程中形态破坏的阶段。

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