• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Urology and Nephrology >Elevated neutrophil to lymphocyte ratio predicts overall and cardiovascular mortality in maintenance peritoneal dialysis patients
【24h】

Elevated neutrophil to lymphocyte ratio predicts overall and cardiovascular mortality in maintenance peritoneal dialysis patients

机译：中性粒细胞与淋巴细胞比例的升高可预测维持性腹膜透析患者的总体死亡率和心血管死亡率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Neutrophil to lymphocyte ratio (NLR) is widely used as a marker of inflammation and an indicator of cardiovascular outcomes in patients with coronary artery disease. However, its prognostic value in peritoneal dialysis (PD) patients is still unknown. Methods: We studied 138 newly started PD patients and 60 healthy controls at the First AffiliatedHospital of Sun Yat-Sen University, Guangzhou, China. Baseline NLR as well as demographic, clinical, and biochemical parameters were recorded. All patients were followed up untilMarch 2011 to evaluate mortality as the primary outcome. Overall and cardiovascular disease-free survival rates were compared according to NLR level. Multivariate analysis was performed to assess the prognostic value of NLR. Results: Baseline NLR levels (mean 3.5 ± 1.6) were significantly increased in PD patients compared to healthy controls (mean 1.5 ± 0.5; P<0.001). Patients with higher NLR had a higher mortality rate compared with patients with lower NLR (51.5% vs 22.9%; P = 0.006). The 1-year and 3-year overall survival rates were 86.6% and 65.9% for patients with higher NLR compared with 97% and 85.1% for patients with lower NLR (P = 0.006). Patients with higher NLR also showed a higher cardiovascular mortality rate, compared with patients with lower NLR (38% vs 7.6%; P = 0.003). The 1-year and 3-year cardiovascular event-free survival rates were 90.7% and 81.9% for patients with higher NLR, compared with 98.6% and 95.1% for patients with lower NLR. Multivariate analysis showed high NLR value was an independent risk factor for all-cause and cardiovascular mortality. Conclusion: Neutrophil to lymphocyte ratio is a strong predictor for overall and cardiovascular mortality in PD patients.
机译：背景中性粒细胞与淋巴细胞的比率（NLR）被广泛用作炎症标志物和冠心病患者的心血管预后指标。然而，其在腹膜透析（PD）患者中的预后价值仍然未知。方法：我们在中国广州市中山大学附属第一医院研究了138名新开始的PD患者和60名健康对照。记录基线NLR以及人口统计，临床和生化参数。所有患者均接受随访，直至2011年3月，以死亡率作为主要结局。根据NLR水平比较总体生存率和无心血管疾病生存率。进行多变量分析以评估NLR的预后价值。结果：与健康对照组相比，PD患者的基线NLR水平（平均3.5±1.6）显着增加（平均1.5±0.5; P <0.001）。 NLR较高的患者与NLR较低的患者相比死亡率更高（51.5％vs 22.9％; P = 0.006）。 NLR较高的患者1年和3年总生存率分别为86.6％和65.9％，而NLR较低的患者分别为97％和85.1％（P = 0.006）。 NLR较高的患者与NLR较低的患者相比，心血管死亡率更高（38％比7.6％; P = 0.003）。 NLR较高的患者的1年和3年无心血管事件生存率分别为90.7％和81.9％，而NLR较低的患者为98.6％和95.1％。多变量分析显示，高NLR值是全因和心血管疾病死亡率的独立危险因素。结论：中性粒细胞与淋巴细胞的比率是PD患者总体死亡率和心血管死亡率的有力预测指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号