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首页> 外文期刊>Investigative radiology >Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications.
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Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications.

机译：微泡造影剂：靶向超声成像和超声辅助药物递送应用。

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The use of microbubble contrast agents for general tissue delineation and perfusion enjoys steady interest in ultrasound imaging. Microbubbles as contrast materials require a small dosage and show excellent detection sensitivity. Targeting ligands on the surface of microbubbles permit the selective accumulation of these particles in the areas of interest, which show an up-regulated level of receptor molecules on vascular endothelium. Selective contrast imaging of inflammation, ischemia-reperfusion injury, angiogenesis, and thrombosis has been achieved in animal models. Ultrasound-assisted drug delivery and activation, performed by combining microbubble agent containing drug substances or coadministered with pharmaceutical agents (including plasmid DNA for transfection), has been achieved in multiple model systems in vitro and in vivo. Ultrasound and microbubbles-based targeted acceleration of the thrombolytic enzyme action already have reached clinical trials. Overall, microbubble targeting and ultrasound-assisted microbubble-based drug-delivery systems will offer a step toward the application of targeted personalized diagnostics and therapy.
机译：将微泡造影剂用于一般组织描绘和灌注在超声成像中一直引起人们的关注。微气泡作为对比材料，需要的剂量很小，并且显示出出色的检测灵敏度。微泡表面上的靶向配体允许这些颗粒在感兴趣区域中选择性积聚，这表明血管内皮细胞上的受体分子水平上调。在动物模型中已经实现了炎症，缺血再灌注损伤，血管生成和血栓形成的选择性对比成像。通过结合含有药性物质的微泡剂或与药剂（包括用于转染的质粒DNA）共同给药进行超声辅助的药物递送和激活，已在体外和体内的多种模型系统中实现。基于超声和微气泡的血栓溶解酶作用的靶向加速已经达到临床试验。总体而言，微气泡靶向和超声辅助的基于微气泡的药物递送系统将为定向个性化诊断和治疗的应用迈出一步。

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