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首页> 外文期刊>International journal of surgical pathology >Epithelial-Myoepithelial Carcinoma of the Salivary Gland Harboring HRAS Codon 61 Mutations With Lung Metastasis
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Epithelial-Myoepithelial Carcinoma of the Salivary Gland Harboring HRAS Codon 61 Mutations With Lung Metastasis

机译：唾液腺上皮-肌上皮癌HRAS密码子61突变与肺转移。

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Here, we report a case involving a 43-year-old man diagnosed with Burkitt lymphoma in 2007. At the same time, 2 small lung nodules were incidentally found; however, they presented no indication of growth throughout the follow-up period. However, a 1.5-cm nodule located in the right parotid gland in 2010 gradually increased in size to 2.8 cm by 2012. A parotidectomy revealed an epithelial-myoepithelial carcinoma, characterized by biphasic tubular structures and solid areas presenting myoepithelial overgrowth. Tumor necrosis and regional lymph node invasion were also observed. During clinical follow-up in 2013, a new 1.3-cm nodule was identified in the left lower lobe of the lung, which enlarged to 3 cm by 2014. Wedge resection of the left lung nodules revealed round nodes with well-defined borders. Histologically, these lung tumors predominantly comprised spindle-shaped myoepithelial cells with occasional tubular structures. Numerous cleft-like spaces lined by entrapped TTF-1-immunoreactive pneumocytes were observed inside the nodules. The lung nodules were characterized by a morphology similar to that of the parotid cancer. Epithelial-myoepithelial carcinoma with lung metastasis was confirmed by molecular testing, which revealed identical HRAS codon 61 (Q61K) mutations in the primary parotid tumor as well as in the lung metastases.
机译：在这里，我们报道一例涉及2007年诊断为Burkitt淋巴瘤的43岁男子。与此同时，偶然发现2个小肺结节;其中2个肺结节被发现。然而，他们没有在整个随访期间显示出增长的迹象。然而，2010年位于右腮腺的1.5厘米结节大小逐渐增加，到2012年增至2.8厘米。腮腺切除术显示上皮肌上皮癌，其特征为双相小管结构和实体区域，显示肌上皮过度生长。还观察到肿瘤坏死和局部淋巴结浸润。在2013年的临床随访期间，在肺的左下叶中发现了一个新的1.3厘米结节，到2014年扩大到3厘米。对左肺结节进行楔形切除术发现圆形结节边界清晰。从组织学上讲，这些肺肿瘤主要包括纺锤形的肌上皮细胞，偶有管状结构。在结节内观察到许多由截留的TTF-1免疫反应性肺细胞包裹的裂口状空间。肺结节的特征与腮腺癌的形态相似。通过分子测试证实了具有肺转移的上皮-肌上皮癌，其揭示了在原发腮腺肿瘤以及肺转移中相同的HRAS密码子61（Q61K）突变。

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