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首页> 外文期刊>International journal of surgical pathology >RET/PTC rearrangement occurring in primary peritoneal carcinoma.
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RET/PTC rearrangement occurring in primary peritoneal carcinoma.

机译：RET / PTC重排发生在原发性腹膜癌中。

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RET/PTC rearrangements are initiating events in the development of a significant proportion of papillary thyroid carcinomas. Activated RET/PTC mutations are thought to be restricted to thyroid disease, but this study proposes that these events may also occur in nonthyroid tumors. A total of 57 nonthyroid papillary tumors were examined for RET/PTC rearrangements using interphase fluorescence in situ hybridization, Taqman reverse transcriptase polymerase chain reaction, and immunohistochemistry. Taqman single nucleotide polymorphism detection was used to analyze for expression of mutated BRAF T1799A. In all, 20% (3/15) of primary peritoneal carcinoma had detectable RET/PTC1 rearrangements by all 3 methodologies. A further case of similar histotype had an alternate RET/ PTC rearrangement. No RET/PTC1 rearrangements were detected in the remaining tumor cohort. All 57 tumors were homozygous for wild-type BRAF. The results indicate that RET/PTC rearrangements occur in a small subset of nonthyroid papillary tumors. These rearrangements may not be directly implicated in tumor growth; rather representing "passenger" mutations reflecting RET instability in secondary tumor subclones.
机译：RET / PTC重排是甲状腺乳头状癌发展中的重要事件。激活的RET / PTC突变被认为仅限于甲状腺疾病，但这项研究表明，这些事件也可能发生在非甲状腺肿瘤中。使用相间荧光原位杂交，Taqman逆转录酶聚合酶链反应和免疫组化技术，共检查了57个非甲状腺乳头状瘤的RET / PTC重排。 Taqman单核苷酸多态性检测用于分析BRAF T1799A突变的表达。通过所有三种方法，总共有20％（3/15）的原发性腹膜癌具有可检测到的RET / PTC1重排。另一例相似的组织类型病例发生了RET / PTC的重排。在其余的肿瘤队列中未检测到RET / PTC1重排。对于野生型BRAF，所有57个肿瘤都是纯合的。结果表明，RET / PTC重排发生在一小部分非甲状腺乳头状肿瘤中。这些重排可能与肿瘤的生长没有直接关系。而是代表“客体”突变，反映了继发性肿瘤亚克隆中的RET不稳定性。

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