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首页> 外文期刊>Biochemical Pharmacology >FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene.
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FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene.

机译：白藜芦醇类似物3,4,5-三羟基-反式-二苯乙烯在Jurkat白血病T细胞中诱导FADD依赖性凋亡。

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摘要

The plant-produced compound, resveratrol (3,5,4'-trihydroxy-trans-stilbene, 3,4,5-THS), induces apoptosis in various human leukemia cell types in vitro, and thus appears to be a promising anti-leukemia agent. In this study, we observed that treatment of resveratrol-resistant Jurkat cells with the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene (3,4,5-THS), rapidly induced extensive apoptosis, indicating that the apoptotic activity of the analogue differed from that of the parental compound resveratrol. Indeed, we found that treatment of Jurkat cells with 3,4,5-THS, unlike treatment with resveratrol, induced activation of caspase-8 and apoptosis by a Fas-associated death domain (FADD) protein-dependent mechanism without involving the known death ligands CD95 ligand (CD95L), tumor necrosis factor alpha (TNFalpha) and TNF-related apoptosis-inducing ligand (TRAIL). Therefore, 3,4,5-THS induced activation of a FADD-dependent apoptotic mechanism that was unresponsive to the parental compound resveratrol. Therefore, the ability of 3,4,5-THS, but not resveratrol, to induce apoptosis demonstrates a structure-associated apoptotic activity of the resveratrol analogue.
机译：植物产生的化合物白藜芦醇（3,5,4'-三羟基-反式-二苯乙烯，3,4,5-THS）在体外诱导多种人类白血病细胞凋亡，因此似乎是一种有前途的抗白血病剂。在这项研究中，我们观察到用白藜芦醇类似物3,4,5-三羟基-反式-二苯乙烯（3,4,5-THS）处理白藜芦醇抗性Jurkat细胞，迅速诱导了广泛的细胞凋亡，表明其凋亡活性的类似物不同于母体化合物白藜芦醇。确实，我们发现，与白藜芦醇处理不同，用3,4,5-THS处理Jurkat细胞可通过Fas相关死亡域（FADD）蛋白依赖性机制诱导caspase-8激活和凋亡，而不会涉及已知死亡CD95配体（CD95L），肿瘤坏死因子α（TNFalpha）和TNF相关凋亡诱导配体（TRAIL）。因此，3,4,5-THS诱导了对亲本化合物白藜芦醇无反应的FADD依赖性凋亡机制的激活。因此，3,4,5-THS而非白藜芦醇诱导凋亡的能力证明了白藜芦醇类似物的结构相关的凋亡活性。

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