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首页> 外文期刊>Inverse Problems in Science & Engineering >Characterization of stress-strain behaviour of red blood cells (RBCs), part I: methodology development and application to healthy RBCs
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Characterization of stress-strain behaviour of red blood cells (RBCs), part I: methodology development and application to healthy RBCs

机译：红细胞（RBC）应力应变行为的特征，第一部分：方法学的发展和对健康RBC的应用

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摘要

Deformation characteristics of red blood cells (RBCs) are closely linked to disease progression and hold promise as a tool for disease diagnosis. Recent studies have been conducted to measure these deformation characteristics using optical tweezers. Models of RBCs are developed to reproduce some of these measurements and to gain insights into the mechanical behaviour of RBCs. In this paper, a new inverse analysis approach, SelfSim (Self-Learning Simulations), is introduced to extract RBC material stress-strain behaviour from complementary boundary measurements of forces and displacements obtained by optical tweezers. SelfSim inverse analysis approach allows the user to discover new material stress-strain relationships to best reproduce the global force-displacement measurements. SelfSim is verified using simulated RBC experiments and then applied to physical measurements on healthy RBC. SelfSim reveals that in order to capture the interrelationship between measured axial and transverse deformations, the stress-strain relationship for healthy RBCs has to be anisotropic and thus differs from commonly assumed isotropic hyperelastic response.
机译：红细胞（RBC）的变形特征与疾病进展密切相关，并有望作为疾病诊断的工具。最近进行了研究，以使用光镊测量这些变形特性。开发了RBC的模型以重现其中一些测量值，并深入了解RBC的机械性能。在本文中，一种新的反分析方法SelfSim（自学习模拟）被引入，用于从光学镊子获得的力和位移的互补边界测量中提取RBC材料的应​​力-应变行为。 SelfSim逆分析方法允许用户发现新的材料应力-应变关系，以最佳地再现整体力-位移测量值。使用模拟的RBC实验验证SelfSim，然后将其应用于健康RBC的物理测量。 SelfSim揭示，为了捕获测得的轴向变形和横向变形之间的相互关系，健康RBC的应力-应变关系必须是各向异性的，因此不同于通常假定的各向同性超弹性响应。

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