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Paired-Like Subclass Homeobox Genes from the Clitellate Annelid Perionyx excavatus

机译:纤毛状Annelid Perionyx excavatus的成对亚类同源异型框基因

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摘要

The homeobox genes compose a large family of genes encoding for transcription factor proteins. A motif of 60 amino acids termed the homeodomain has been intensively studied in order to elucidate the molecular mechanism of the specification of body pattern during embryonic development, differentiation, and regeneration (Scott et al. 1989; Gehring et al. 1990). In the past decade, various classification systems have been proposed for the categorization of homeobox genes (Biirglin 1994). These homeobox gene classes can be grouped into a few large superclasses, based on the results of molecular phylogenetic analyses. Homeodomain proteins are generally classified into 11 classes: Hox, NK, Paired, POU, LIM, TALE, SIX, Prox, Cut, ZFH, and HNF1 (Wada et al. 2003). The Paired class is subdivided into two subclasses, namely, the Paired-like subclass, including the Q50 and K50 genes, and the Pax-type subclass, which includes the S50 genes (Galliot et al. 1999).
机译:同源异型框基因组成了编码转录因子蛋白的大量基因家族。为了阐明在胚胎发育,分化和再生过程中体型规范的分子机制,已经对60个氨基酸的基序域进行了深入研究(Scott等,1989; Gehring等,1990)。在过去的十年中,已经提出了各种分类系统用于同源盒基因的分类(Biirglin 1994)。基于分子系统发育分析的结果,这些同源异型盒基因类别可以分为几个大的超类。同源结构域蛋白通常分为11类:Hox,NK,成对,POU,LIM,TALE,SIX,Prox,Cut,ZFH和HNF1(Wada等人,2003年)。 Paired类可细分为两个子类,即Paired-like子类,包括Q50和K50基因; Pax-type子类,包括S50基因(Galliot等,1999)。

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