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Screening of endocrine disruption activity in sediments from the Uruguay River

机译：乌拉圭河沉积物中内分泌干扰活性的筛选

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Sediment constitutes an important sink of endocrine disruptor compounds; however, the potential of sediments to act as a source of endocrine disruptors should be more extensively investigated. The main objective of this study was to determine whether exposure of immature common carp to Uruguay River sediments undergo physiological and endocrine alterations. The lower Uruguay River watershed supports intensive agricultural and forest production, receives municipal sewage discharge and industrial effluent, and a new large pulp mill was constructed in 2006. A 30-day semi-static assay was performed using sediments from four sites along the Uruguay River and compared with an unexposed group in dechlorinated water as a negative control. We focused on two upstream and two downstream sites of a new elemental chlorine free pulp mill. The results showed that plasma vitellogenin levels increased in fish along the river and significant differences were found between the exposed and unexposed groups. Condition factor and gonadosomatic index were not different; however, a significant difference in hepatosomatic index was observed in fish exposed to sediment from an industrial site. A significant reduction in primary spermatocyte accumulation was observed in the exposed group compared with that in the control group, and some individuals exposed to sediments from industrial sites presented with testis-ova. Our results suggest that Uruguay River sediments act as an important source of estrogenic compounds that could be responsible for the alterations observed. Future studies are needed to identify the causal agents and determine exposure routes.
机译：沉积物是内分泌干扰物重要的汇聚区。但是，应该更广泛地研究沉积物作为内分泌干扰物来源的潜力。这项研究的主要目的是确定未成熟鲤鱼对乌拉圭河沉积物的暴露是否发生了生理和内分泌变化。乌拉圭河下游流域支持集约化农业和森林生产，接收市政污水和工业废水，并于2006年建造了一座新的大型纸浆厂。利用来自乌拉圭河沿岸四个地点的沉积物进行了为期30天的半静态分析并与未接触过氯化铁的组作为阴性对照。我们专注于新建无氯元素制浆厂的两个上游和两个下游站点。结果表明，沿河鱼类的血浆卵黄蛋白原水平升高，暴露组和未暴露组之间存在显着差异。条件因子和性腺体指数无差异。然而，在暴露于工业现场沉积物的鱼中，观察到的肝体指数存在显着差异。与对照组相比，暴露组的原代精子细胞积聚明显减少，一些个体暴露于来自睾丸卵的工业场所沉积物。我们的结果表明，乌拉圭河的沉积物是雌激素化合物的重要来源，可能与观测到的变化有关。需要进一步的研究来确定病因并确定暴露途径。

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