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首页> 外文期刊>Ecotoxicology >Critical body residues, Michaelis-Menten analysis of bioaccumulation, lethality and behaviour as endpoints of waterborne Ni toxicity in two teleosts
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Critical body residues, Michaelis-Menten analysis of bioaccumulation, lethality and behaviour as endpoints of waterborne Ni toxicity in two teleosts

机译：关键的身体残留物，Michaelis-Menten分析了两种硬骨鱼中水基镍毒性的生物蓄积性，致死性和行为

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Traditionally, water quality guidelines/criteria are based on lethality tests where results are expressed as a function of waterborne concentrations (e.g. LC50). However, there is growing interest in the use of uptake and binding relationships, such as biotic ligand models (BLM), and in bioaccumulation parameters, such as critical body residue values (e.g. CBR50), to predict metal toxicity in aquatic organisms. Nevertheless, all these approaches only protect species against physiological death (e.g. mortality, failed recruitment), and do not consider ecological death which can occur at much lower concentrations when the animal cannot perform normal behaviours essential for survival. Therefore, we investigated acute (96 h) Ni toxicity in two freshwater fish species, the round goby (Neogobius melanostomus) and rainbow trout (Oncorhynchus mykiss) and compared LC, BLM, and CBR parameters for various organs, as well as behavioural responses (spontaneous activity). In general, round goby were more sensitive. Ni bioaccumulation displayed Michaelis-Menten kinetics in most tissues, and round goby gills had lower Kd (higher binding affinity) but similar B max (binding site density) values relative to rainbow trout gills. Round goby also accumulated more Ni than did trout in most tissues at a given exposure concentration. Organ-specific 96 h acute CBR values tended to be higher in round goby but 96 h acute CBR50 and CBR10 values in the gills were very similar in the two species. In contrast, LC50 and LC10 values were significantly higher in rainbow trout. With respect to BLM parameters, gill log K NiBL values for bioaccumulation were higher by 0.4-0.8 log units than the log KNiBL values for toxicity in both species, and both values were higher in goby (more sensitive). Round goby were also more sensitive with respect to the behavioural response, exhibiting a significant decline of 63-75 % in movements per minute at Ni concentrations at and above only 8 % of the LC50 value; trout exhibited no clear behavioural response. Across species, diverse behavioral responses may be more closely related to tissue Ni burdens than to waterborne Ni concentrations. To our knowledge, this is the first study to link Ni bioaccumulation with behavioural endpoints. In future it would be beneficial to expand these analyses to a wider range of species to determine whether Ni bioaccumulation, specifically in the gills, gut and whole fish, may be a good predictor of behavioural changes from metal exposure; which in the wild can lead to ecological death.
机译：传统上，水质指南/标准基于杀伤力测试，其中结果表示为水浓度的函数（例如LC50）。但是，人们越来越关注利用摄取和结合关系（例如生物配体模型（BLM））以及生物蓄积参数（例如关键的身体残基值（例如CBR50））来预测水生生物中的金属毒性。然而，所有这些方法仅能保护物种免受生理性死亡（例如，死亡，招募失败），并且不考虑生态死亡，当动物无法执行生存所必需的正常行为时，生态死亡的浓度可能低得多。因此，我们调查了两种淡水鱼（虾虎鱼（Neogobius melanostomus）和虹鳟鱼（Oncorhynchus mykiss））的急性（96 h）Ni毒性，并比较了各种器官的LC，BLM和CBR参数以及行为反应（自发活动）。总的来说，round鱼比较敏感。镍的生物积累在大多数组织中均表现出Michaelis-Menten动力学，并且圆形虾虎鱼lower的Kd（结合亲和力较高）较低，但B max（结合位点密度）值与虹鳟鱼similar相似。在给定的暴露浓度下，go鱼比大多数鳟鱼还积累了比鳟鱼更多的镍。 round虾的特定于器官的96 h急性CBR值往往较高，但two的96 h急性CBR50和CBR10值在两个物种中非常相似。相反，虹鳟鱼的LC50和LC10值明显更高。关于BLM参数，两种物种的g累积log K NiBL值均比毒性的log KNiBL值高0.4-0.8 log个单位，虾虎鱼的两个值均较高（敏感性更高）。轮虾对行为反应也更敏感，在Ni浓度仅为LC50值的8％或以上时，每分钟运动的速度显着下降63-75％。鳟鱼没有明显的行为反应。在整个物种中，不同的行为反应可能与组织中的Ni含量更密切相关，而不是与水性Ni浓度相关。据我们所知，这是第一项将镍生物蓄积与行为终点联系起来的研究。将来，将这些分析扩展到更大范围的物种，以确定镍的生物蓄积（特别是在the，肠道和整条鱼中）是否可能是金属暴露引起的行为变化的良好预测指标，将是有益的;在野外会导致生态死亡。

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