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Laboratory Exercises; Designing Laboratory Exercises for the Undergraduate Molecular Biology/Biochemistry Student: Techniques and Ethical Implications Involved in Personalized Medicine

机译：实验室练习;为本科生分子生物学/生物化学专业学生设计实验室练习：涉及个性化医学的技术和伦理意义

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摘要

Personalized medicine refers to medical care that involves genetically screening patients for their likelihood to develop various disorders. Commercial genome screening only involves identifying a consumer's genotype for a few single nucleotide polymorphisms. A phenotype (such as an illness) is greatly influenced by three factors: genes, gene expression levels, and the environment. The information supplied by personal genomics companies only involves genes and as such is not always indicative of a particular phenotype. Here, we propose a method for developing modular undergraduate laboratories that examine each contributing factor for a single gene. Although each module is suitable as an individual laboratory exercise, every module may be used in the same class to examine a single phenotype of interest, give students a more complete understanding of how a phenotype is produced and allow students to understand the science behind personalized medicine.
机译：个性化医学是指对患者进行各种疾病的遗传筛查的医疗服务。商业基因组筛选仅涉及确定消费者的基因型是否存在一些单核苷酸多态性。表型（例如疾病）在很大程度上受三个因素的影响：基因，基因表达水平和环境。个人基因组学公司提供的信息仅涉及基因，因此并不总是表示特定的表型。在这里，我们提出了一种开发模块化的本科实验室的方法，该实验室检查单个基因的每个促成因素。尽管每个模块都适合作为单独的实验室练习，但是每个模块都可以在同一课程中使用，以检查单个感兴趣的表型，让学生更全面地了解表型的产生方式，并使学生了解个性化医学背后的科学。

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