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首页> 外文期刊>Biochemical Genetics >Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese Black beef.
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Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese Black beef.

机译：FASN基因的新突变及其对日本黑牛肉中脂肪酸组成的影响。

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摘要

Eight novel and four known mutations were detected in the coding sequence of the bovine fatty acid synthase (FASN) gene of an F2 population from Japanese Black and Limousin cattle. Two mutations, g.16024A>G and g.16039T>C, detected in exon 34, which determine amino acid substitutions of threonine (T) to alanine (A) and tryptophan (W) to arginine (R), were clearly separated in the parental breeds. The haplotypes (TW and AR) segregated in F2 individuals and had a significant effect on the fatty acid composition of backfat, intermuscular fat, and intramuscular fat. The TW haplotype was associated with increasing C18:0 and C18:1 content and the ratio of monounsaturated to saturated fatty acids, and decreasing C14:0, C14:1, C16:0, and C16:1 content. The two mutations were screened in two commercial Japanese Black half-sibling populations and similarly determined the contribution to the fatty acid composition of intramuscular fat. The frequency of the TW haplotype was markedly higher in Japanese Black (0.67) than in Holstein (0.17), Angus (0.02), and Hereford (0.07). We conclude that these mutations may contribute to the characteristic fatty acid composition of Japanese Black beef.
机译：在来自日本黑和利木赞牛的F2群体的牛脂肪酸合酶（FASN）基因的编码序列中检测到八个新的和四个已知的突变。在第34外显子中检测到两个突变，分别为g.16024A> G和g.16039T> C，这些突变确定了苏氨酸（T）取代为丙氨酸（A）和色氨酸（W）取代为精氨酸（R）的氨基酸。父母的品种。单倍型（TW和AR）在F2个体中分离，并且对后发脂肪，肌间脂肪和肌内脂肪的脂肪酸组成具有显着影响。 TW单倍型与增加C18：0和C18：1含量以及单不饱和脂肪酸与饱和脂肪酸的比率以及降低C14：0，C14：1，C16：0和C16：1含量有关。在两个商业的日本黑半兄弟姐妹人群中筛选了这两个突变，并类似地确定了它们对肌内脂肪脂肪酸组成的贡献。 TW单倍体的发生率在日本黑人（0.67）中明显高于荷斯坦（0.17），安格斯（0.02）和赫里福德（0.07）。我们得出结论，这些突变可能有助于日本黑牛肉的特征脂肪酸组成。

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