...
首页> 外文期刊>Biochemical Genetics >Novel single nucleotide polymorphisms of the caprine PC1 gene and association with growth traits.
【24h】

Novel single nucleotide polymorphisms of the caprine PC1 gene and association with growth traits.

机译:鼠PC1基因的新型单核苷酸多态性及其与生长性状的关联。

获取原文
获取原文并翻译 | 示例
           

摘要

Proprotein convertase 1 (PC1) is an endopeptidase involved in proteolytic processing of peptide hormone precursors in granules of the regulated secretory pathway in endocrine cells. Mutations in the PC1 gene are thought to cause obesity, and multiple alternatively spliced transcript variants have been described for this gene. In this study, based on PCR-SSCP and DNA sequencing methods, polymorphisms of the PC1 gene were detected in 447 individuals from three breeds. Only the P1, P2, P3, P9, and P10 loci showed polymorphisms, and 12 SNPs in the PC1 gene were identified. Additionally, an association analysis between mutations in the 5'-UTR and four growth traits indicated that the polymorphisms were significantly associated with caprine body height (P < 0.05) and chest circumference (P < 0.01).
机译:前蛋白转化酶1(PC1)是一种内肽酶,参与内分泌细胞中调节性分泌途径颗粒中肽激素前体的蛋白水解加工。人们认为PC1基因中的突变会导致肥胖,并且已经针对该基因描述了多个选择性剪​​接的转录变体。在这项研究中,基于PCR-SSCP和DNA测序方法,在三个品种的447个人中检测到PC1基因的多态性。仅P1,P2,P3,P9和P10位点显示多态性,并且在PC1基因中鉴定出12个SNP。此外,在5'-UTR突变与四个生长性状之间的关联分析表明,多态性与山羊体高(P <0.05)和胸围(P <0.01)显着相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号