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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >Study on enantiomeric separation of basic drugs by NACE in methanol-based medium using erythromycin lactobionate as a chiral selector.
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Study on enantiomeric separation of basic drugs by NACE in methanol-based medium using erythromycin lactobionate as a chiral selector.

机译：以乳酸红霉素为手性选择剂的甲醇基培养基中NACE对基础药物的对映体分离研究。

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摘要

A wide variety of chiral selectors have been employed in CZE, and among them macrocyclic antibiotics including glycopeptides, ansamycins, aminoglycosides and polypeptides exhibited prominent enantioselective properties toward abundant racemic compounds. Compared with CZE, the use of macrocyclic antibiotics as chiral selectors in NACE has not been reported previously. In this study, an approach to the enantioseparation of basic drugs by means of NACE with erythromycin lactobionate (EL) belonging to the group of macrolide antibiotics has been investigated. Especially different from the above four classes of antibiotics, there are no reports concerned with the use of macrolides which belong to macrocyclic antibiotics as chiral selectors in CE. In this work EL is first used as a chiral selector in NACE for the enantiomeric separations of two racemic basic drugs that possess high separability consisting of propranolol and duloxetine. Furthermore, EL possesses advantages such as high solubility and low viscosity in the solvent and very weak UV absorption. The chiral separations were achieved using Tris-boric acid as the BGE and methanol as the organic medium. In the course of this work we observed that both migration time and enantioseparation were influenced by several parameters such as the pH and composition of the BGE, EL concentration, capillary temperature and applied voltage. Consequently, these parameters were systematically optimized in order to obtain the optimum enantioseparations.
机译：多种手性选择剂已用于CZE，其中大环抗生素包括糖肽，安沙霉素，氨基糖苷和多肽对丰富的外消旋化合物表现出突出的对映选择性。与CZE相比，以前没有在NACE中使用大环抗生素作为手性选择剂的报道。在这项研究中，已研究了通过NACE与属于大环内酯类抗生素的乳酸红霉素（EL）对映分离基本药物的方法。特别是与上述四种抗生素不同的是，没有关于使用属于大环抗生素的大环内酯类化合物作为CE中手性选择剂的报道。在这项工作中，EL首先在NACE中用作手性选择剂，用于分离由普萘洛尔和度洛西汀组成的具有高可分离性的两种外消旋基本药物的对映异构体。而且，EL具有诸如在溶剂中的高溶解度和低粘度以及非常弱的UV吸收之类的优点。使用三硼酸作为BGE，甲醇作为有机介质，实现了手性分离。在这项工作的过程中，我们观察到迁移时间和对映体分离都受到几个参数的影响，例如BGE的pH和组成，EL浓度，毛细管温度和施加电压。因此，系统地优化了这些参数以获得最佳的对映体。

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