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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >Thermal marks as a signal processing aid for a portable capillary electropherograph.
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Thermal marks as a signal processing aid for a portable capillary electropherograph.

机译：热标记作为便携式毛细管电泳仪的信号处理辅助工具。

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摘要

The interpretation of raw signals in capillary CE can be challenging if there are unknown peaks, or the signal is corrupt due to baseline fluctuations, EOF velocity drift, etc. Signal processing could be required before results can be interpreted. A suite of signal processing algorithms has been developed for CE data analysis, specifically for use in field experiments for the detection of nerve agents using portable CE instruments. Everything from baseline correction and electropherogram alignment to peak matching and identification is included in these programs. Baseline correction is achieved by interpolating a new baseline according to points found using all local extremes, by applying an appropriate outliers test. Irreproducible migration times are corrected by compensating for EOF drift, measured with the aid of thermal marks. Thermal marks are small disturbances in the capillary created by punctual heating that move with the velocity of EOF. Peaks in the sample electropherogram are identified using a fuzzy matching algorithm, by comparing peaks from the sample electropherogram to peaks from a reference electropherogram.
机译：如果存在未知峰，或者由于基线波动，EOF速度漂移等原因导致信号损坏，则毛细管毛细管CE中原始信号的解释可能会遇到挑战。在解释结果之前可能需要进行信号处理。已开发出一套用于CE数据分析的信号处理算法，专门用于在现场实验中使用便携式CE仪器检测神经毒剂。这些程序包括从基线校正和电泳图校正到峰匹配和鉴定的所有内容。通过应用适当的离群值检验，根据使用所有局部极值找到的点内插新基线，可以实现基线校正。不可弥补的迁移时间通过补偿EOF漂移（通过热标记测量）进行校正。热斑是由于点加热引起的毛细管中的细小扰动，随EOF的速度而移动。通过将样品电泳图谱中的峰与参考电泳图谱中的峰进行比较，可以使用模糊匹配算法识别样品电泳图谱中的峰。

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