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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >Recent advances in miniaturization-The role of microchip electrophoresis in clinical analysis
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Recent advances in miniaturization-The role of microchip electrophoresis in clinical analysis

机译：微型化的最新进展-微芯片电泳在临床分析中的作用

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This review is a follow-up from the last review published in 2012 that covers the same topic [22]. Its aim is to cover new innovations and developments since then, involving the role of microchip capillary electrophoresis (MCE) in clinical analysis. MCE has shown great promise in separation science, as it's a state-of-the-art analytical separation technique that offers speed, portability, reduced sample, and reagent requirements, repeatability, can be used online or offline, and can be coupled with many kinds of analytical detectors. It is particularly important in clinical analysis, as it offers online continuous monitoring, can handle small volumes of highly complex biological samples due to its powerful discriminating ability, and it facilitates point-of-care testing. Also microchip separation platforms have been used for sample clean-up, filtration, derivatization, separation and detection, acting as multifunctional platforms ideal for minute sample volumes. In recent times the clinical world has witnessed a need for rapid turnaround times on analysis of very complex samples, and so there has been a shift toward point-of-care testing and other miniaturized analytical techniques as a favorable solution. Research developments in this area have been catalyzed by rapid strides in knowledge in the areas of proteomics, metabolomics, and molecular biology in the quest to understand the physiology of cells, proteins, genes, molecular interactions, and the pathophysiology of disease. Herein, we present selected examples detailing the use of MCE in some of the latest and most exciting clinical applications.
机译：这篇评论是2012年发布的最新评论的后续内容，该评论涵盖了相同的主题[22]。此后的目的是涵盖新的创新和发展，涉及微芯片毛细管电泳（MCE）在临床分析中的作用。 MCE在分离科学领域显示出巨大的希望，因为它是一种最先进的分析分离技术，可提供速度，便携性，减少的样品和试剂要求，可重复性，可在线或离线使用，并可与许多其他方法结合使用各种分析探测器。它在临床分析中尤为重要，因为它提供了在线连续监控功能，由于其强大的辨别能力，可以处理少量的高度复杂的生物样品，并且便于即时检测。微芯片分离平台也已用于样品净化，过滤，衍生化，分离和检测，是微量样品的理想多功能平台。近年来，临床世界已经见证了对非常复杂的样品进行分析需要快速的周转时间的趋势，因此，已经朝着即时检验和其他小型化分析技术发展的趋势发展。蛋白质组学，代谢组学和分子生物学领域的知识迅速发展，促进了该领域的研究发展，以期了解细胞，蛋白质，基因，分子相互作用和疾病的病理生理学。本文中，我们提供了一些示例，详细介绍了MCE在某些最新和最令人兴奋的临床应用中的使用。

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