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首页> 外文期刊>International Journal of Medicinal Mushrooms >Chemical Composition and Antiproliferative, Antioxidant, and Proapoptotic Effects of Fruiting Body Extracts of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), from India
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Chemical Composition and Antiproliferative, Antioxidant, and Proapoptotic Effects of Fruiting Body Extracts of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), from India

机译：灵芝或灵芝药用蘑菇子实体提取物灵芝（Agaricomycetes）的化学成分以及抗增殖，抗氧化和促凋亡作用

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摘要

Ganoderma lucidum is a renowned medicinal mushroom exploited as a panacea because of the broad spectrum of its bioactivities, which give it invaluable nutritional and clinical implications. This research was implemented with an incentive to explore and quantify various macromolecules encompassed in the oriental fungus; these vary in concentration with respect to the development/growth phase, host plants, and geographic location of collection. Chemical profiling of G. lucidum confirmed the presence of myco-constituents, their amounts varying in response to extreme climatic conditions. G. lucidum extract exhibited elevated levels of all myco-constituents but flavonoids, which were more pronounced when in a parasitic relationship with their host plants. Proapoptotic efficiency portrayed by the extracts against a prostate cancer cell line (PC-3) was also found to be similar. The samples collected from the Bathinda region, with Azadirachta and Acacia trees as the host plants, showed several-fold augmentation in levels of G. lucidum gredients compared with other variants. Elevated levels of myco-constituents highlight their significance in inhibiting prostate cancer cell proliferation, reducing reactive oxygen species, suppressing invasive potential, and inducing apoptosis. It was thus concluded that G. lucidum grown on Azadirachta plants was more efficient in exhibiting potent biological activities than G. lucidum grown on other host plants.
机译：灵芝是一种著名的药用蘑菇，由于其广泛的生物活性而被用作灵丹妙药，因此具有重要的营养和临床意义。进行这项研究的动机是探索和量化东方真菌中所包含的各种大分子。这些在浓度方面因发育/生长阶段，寄主植物和收集的地理位置而异。灵芝的化学分析证实了霉菌成分的存在，其含量随极端气候条件而变化。灵芝提取物表现出升高的所有真菌成分，但类黄酮含量高，当与它们的寄主植物有寄生关系时更明显。还发现提取物对前列腺癌细胞系（PC-3）的促凋亡效率相似。与其他变体相比，以印in（Azadirachta）和金合欢（Acacia）树为寄主植物的巴斯廷达地区（Bathinda）地区收集的样品显示灵芝G. lucidum成分的含量增加了数倍。霉菌成分水平的升高突出了其在抑制前列腺癌细胞增殖，减少活性氧种类，抑制侵袭潜能和诱导细胞凋亡方面的重要性。因此得出结论，在印A属植物上生长的灵芝比在其他宿主植物上生长的灵芝更有效地表现出有效的生物活性。

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