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首页> 外文期刊>International Journal of Medicinal Mushrooms >Lion's Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study
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Lion's Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study

机译：狮子的鬃毛，猴头菇和虎奶，木犀牛（高级担子菌）药用蘑菇刺激大脑，脊髓和视网膜离体细胞的神经突生长：一项体外研究。

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Neurodegenerative disease is defined as a deterioration of the nervous system in the intellectual and cognitive capabilities. Statistics show that more than 80-90 million individuals age 65 and above in 2050 may be affected by neurodegenerative conditions like Alzheimer's and Parkinson's disease. Studies have shown that out of 2000 different types of edible and/or medicinal mushrooms, only a few countable mushrooms have been selected until now for neurohealth activity. Hericium erinaceus is one of the well-established medicinal mushrooms for neuronal health. It has been documented for its regenerative capability in peripheral nerve. Another mushroom used as traditional medicine is Lignosus rhinocerotis, which has been used for various illnesses. It has been documented for its neurite outgrowth potential in PC12 cells. Based on the regenerative capabilities of both the mushrooms, priority was given to select them for our study. The aim of this study was to investigate the potential of H. erinaceus and L. rhinocerotis to stimulate neurite outgrowth in dissociated cells of brain, spinal cord, and retina from chick embryo when compared to brain derived neurotrophic factor (BDNF). Neurite outgrowth activity was confirmed by the immunofluorescence method in all tissue samples. Treatment with different concentrations of extracts resulted in neuronal differentiation and neuronal elongation. H. erinaceus extract at 50 mu g/mL triggered neurite outgrowth at 20.47%, 22.47%, and 21.70% in brain, spinal cord, and retinal cells. L. rhinocerotis sclerotium extract at 50 mu g/mL induced maximum neurite outgrowth of 20.77% and 24.73% in brain and spinal cord, whereas 20.77% of neurite outgrowth was observed in retinal cells at 25 mu g/mL, respectively.
机译：神经退行性疾病被定义为神经系统智力和认知能力的恶化。统计数据显示，到2050年，超过80-9000万65岁以上的老年人可能会受到神经退行性疾病的影响，例如阿尔茨海默氏病和帕金森氏病。研究表明，在2000种不同类型的可食用和/或药用蘑菇中，到目前为止，只有少数可计数的蘑菇被选择用于神经健康活动。猴头猴是神经元健康的公认药用蘑菇之一。已经证明其在周围神经中具有再生能力。另一种用作传统药物的蘑菇是木犀牛（Lignosus rhinocerotis），已被用于治疗多种疾病。已有文献报道其在PC12细胞中具有神经突生长潜力。根据两种蘑菇的再生能力，优先选择它们进行研究。这项研究的目的是研究与脑源性神经营养因子（BDNF）相比，猴头孢菌和犀牛刺激从鸡胚分离的脑，脊髓和视网膜分离细胞中的神经突生长的潜力。通过免疫荧光法在所有组织样品中证实了神经突向外生长活性。用不同浓度的提取物处理导致神经元分化和神经元伸长。浓度为50μg / mL的猴头菌提取物在脑，脊髓和视网膜细胞中引发的神经突增生率为20.47％，22.47％和21.70％。 50μg / mL的犀牛硬化菌提取物在脑和脊髓中诱导最大的神经突生长，分别为25. g / mL的20.77％和24.73％，而在视网膜细胞中分别观察到20.77％的神经突生长。

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