Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

Chen Y.; Wan B.; Wang K.C.; Cao F.; Yang Y.; Protacio A.; Dou Y.; Chang H.Y.; Lei M.

首页> 外文期刊>EMBO reports >Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

【24h】

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

机译：人类Ash2L N末端区域的晶体结构显示参与DNA结合的有翼螺旋基序

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Ash2L is a core component of the MLL family histone methyltransferases and has an important role in regulating the methylation of histone H3 on lysine 4. Here, we report the crystal structure of the N-terminal domain of Ash2L and reveal a new function of Ash2L. The structure shows that Ash2L contains an atypical PHD finger that does not have histone tail-binding activity. Unexpectedly, the structure shows a previously unrecognized winged-helix motif that directly binds to DNA. The DNA-binding-deficient mutants of Ash2L reduced Ash2L localization to the HOX locus. Strikingly, a single mutation in Ash2L WH (K131A) breaks the chromatin domain boundary, suggesting that Ash2L also has a role in chromosome demarcation.

机译：Ash2L是MLL家族组蛋白甲基转移酶的核心组成部分，在调节赖氨酸4上组蛋白H3的甲基化中具有重要作用。在这里，我们报道Ash2L N端结构域的晶体结构，并揭示Ash2L的新功能。该结构表明，Ash2L包含不具有组蛋白尾部结合活性的非典型PHD手指。出乎意料的是，该结构显示了以前无法识别的直接与DNA结合的带翼螺旋基序。 Ash2L的DNA结合缺陷型突变体减少Ash2L定位到HOX基因座。令人惊讶的是，Ash2L WH（K131A）中的单个突变打破了染色质结构域边界，表明Ash2L在染色体分界中也有作用。

著录项

来源
《EMBO reports》 |2011年第8期|共7页
作者
Chen Y.; Wan B.; Wang K.C.; Cao F.; Yang Y.; Protacio A.; Dou Y.; Chang H.Y.; Lei M.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
Ash2L; histone methyltransferase; MLL; transcription; winged helix motif;

机译：Ash2L;组蛋白甲基转移酶;MLL;转录;翅螺旋基序;

相似文献

外文文献
中文文献
专利

1. Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding [J] . Chen Y., Wan B., Wang K.C., EMBO reports . 2011,第8期

机译：人类Ash2L N末端区域的晶体结构显示参与DNA结合的有翼螺旋基序
2. Crystal structure of dissimilatory sulfite reductase D (DsrD) protein - Possible interaction with B- and Z-DNA by its winged-helix motif [J] . Mizuno N., Voordouw G., Miki K., Structure . 2003,第9期

机译：亚硫酸盐还原酶D（DsrD）蛋白的晶体结构-可能通过其有翼螺旋基序与B-和Z-DNA相互作用
3. Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen. [J] . Couture JF, de Jesus Tran KP, Roy AM, Protein Science: A Publication of the Protein Society . 2005,第6期

机译：人类3型3α-羟基类固醇脱氢酶晶体结构的比较揭示了“诱导适应”机制和参与雄激素结合的保守基本基序。
4. Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs [C] . Linyong Mao, Zheng, W.J. . 2006

机译：将比较基因组学与从头发现相结合，以鉴定人类转录因子DNA结合基序。
5. The crystal structure of a DNA-binding protein, HucR, from Deinococcus radiodurans R1: A member of the MarR family of winged-helix transcriptional regulators. [D] . Bordelon, Hansen D., IV. 2006

机译：DNA结合蛋白HucR的晶体结构，来自Deinococcus radiodurans R1：有翅螺旋转录调节子MarR家族的成员。
6. Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding [O] . Yong Chen, Bingbing Wan, Kevin C Wang, 2011

机译：人类Ash2L N末端区域的晶体结构显示参与DNA结合的有翼螺旋基序
7. Crystal structure of the N‐terminal region of human Ash2L shows a winged‐helix motif involved in DNA binding [O] . Chen, Yong, Wan, Bingbing, Wang, Kevin C, 2011

机译：人ash2L的N-末端区域的晶体结构显示参与DNa结合的翼状螺旋基序

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

摘要

著录项

相似文献

相关主题

期刊订阅