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首页> 外文期刊>EMBO reports >Towards preventive medicine High-throughput methods from molecular biology are about to change daily clinical practice
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Towards preventive medicine High-throughput methods from molecular biology are about to change daily clinical practice

机译：迈向预防医学分子生物学的高通量方法即将改变日常临床实践

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摘要

MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function. Signalling pathways are ideal candidates for miRNA-mediated regulation owing to the sharp dose-sensitive nature of their effects. Indeed, emerging evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-β, WNt, Notch and epidermal growth factor. As such, miRNAs serve as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.
机译：MicroRNA（miRNA）是基因表达的转录后控制中不可或缺的元素。在鉴定了数百种miRNA之后，现在的挑战是了解它们的特定生物学功能。信号通路由于其效应的敏锐剂量敏感性，因此是miRNA介导调控的理想候选者。实际上，新兴证据表明，miRNA影响细胞对信号分子的响应，例如转化生长因子-β，WNt，Notch和表皮生长因子。因此，miRNA充当信号网络的节点，以确保体内平衡并调节癌症，转移，纤维化和干细胞生物学。

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