A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro.

Lambeir AM; Proost P; Scharpe S; Meester ID

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A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro.

机译：在体外通过二肽基肽酶IV截断胰高血糖素样肽-1和胰高血糖素样肽2的动力学研究。

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摘要

In vivo inactivation of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) was found to be associated with the proteolytic removal of their N-terminal dipeptide by the ectopeptidase dipeptidyl peptidase IV (DPP IV). Previous studies suggested that the in vivo metabolism of GLP-1 is much faster than that of GLP-2. In this paper, we investigated the in vitro truncation of GLP-2 and GLP-1 by DPP IV. The slower conversion rate observed for GLP-2 compared to GLP-1 was due to an approximately 10-fold reduction in catalytic rate constant. The selectivity of DPP IV for the glucagon-like peptides was compared with data obtained for other natural substrates using the same enzyme source in identical conditions.

机译：发现体内胰高血糖素样肽-1（GLP-1）和胰高血糖素样肽2（GLP-2）的失活与通过肽肽酶二肽基肽酶IV（DPP）的N端二肽蛋白水解去除有关。 IV）。先前的研究表明，GLP-1的体内代谢比GLP-2快得多。在本文中，我们研究了DPP IV在体外截短GLP-2和GLP-1的方法。与GLP-1相比，GLP-2的转化率较慢是由于催化速率常数降低了约10倍。将DPP IV对胰高血糖素样肽的选择性与在相同条件下使用相同酶源获得的其他天然底物的数据进行了比较。

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《Biochemical Pharmacology》 |2002年第12期|共4页
作者
Lambeir AM; Proost P; Scharpe S; Meester ID;
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正文语种 eng
中图分类药理学;
关键词
glucagon-like peptide 1; Glucagon-like peptide 2; dipeptidylpeptidase IV;

机译：胰高血糖素样肽1;胰高血糖素样肽2;二肽基肽酶IV;

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1. A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro. [J] . Lambeir AM, Proost P, Scharpe S, Biochemical Pharmacology . 2002,第12期

机译：在体外通过二肽基肽酶IV截断胰高血糖素样肽-1和胰高血糖素样肽2的动力学研究。
2. Glucagon-like peptide-1 (GLP-1) mediates the protective effects of dipeptidyl peptidase IV inhibition on pulmonary hypertension [J] . Jingjing Wang, Min Yu, Jian Xu, Journal of biomedical science. . 2019,第1期

机译：胰高血糖素样肽-1（GLP-1）介导二肽基肽酶IV抑制对肺动脉高压的保护作用
3. Clinical and Physiological Characterization of Elevated Plasma Glucagon-Like Peptide-1 Levels (Hyperglipemia) in a Dipeptidyl Peptidase IV Mutation Carrier [J] . Dandan Zhao, Shaoqian Zhao, Xiao Wang, Frontiers in Endocrinology . 2018,第2期

机译：二肽基肽酶IV突变携带者中血浆胰高血糖素样肽1水平（高血脂）的临床和生理学表征
4. Improved hypoglycemic effect and pharmacokinetics of glucagon-like peptide-1 (GLP-1) by PEGylation [C] . Controlled Release Society annual meeting . 2004

机译：通过聚乙二醇化改善胰高血糖素样肽-1（GLP-1）的降血糖作用和药代动力学
5. In vitro study of human dipeptidyl -peptidase IV: Characterization in serum and kinetic study of peptide truncation [D] . Durinx, Christine 2001

机译：人二肽基肽酶IV的体外研究：血清中的鉴定和肽截短的动力学研究
6. Glucagon-like peptide-1 (GLP-1) mediates the protective effects of dipeptidyl peptidase IV inhibition on pulmonary hypertension [O] . Jingjing Wang, Min Yu, Jian Xu, 2019

机译：胰高血糖素样肽-1（GLP-1）介导二肽基肽酶IV抑制对肺动脉高压的保护作用
7. Dipeptidyl Peptidase IV Inhibition Enhances the Intestinotrophic Effect of Glucagon-Like Peptide-2 in Rats and Mice**This study was supported by grants from The Danish Biotechnology Center for Signal-peptide Research, The Danish Medical Research Council, The Danish Medical Association Research Fund, The Novo Nordisk Foundation, and The Nordisk Research Foundation. [O] . B. Hartmann, J. Thulesen, H. Kissow, 2000

机译：二肽基肽酶IV抑制增强了大鼠和小鼠胰高血糖素肽-2的肠营养效果**本研究由丹麦医学研究委员会，丹麦医学协会研究基金丹麦医学研究委员会的丹麦生物技术中心的补助金支持。，Novo Nordisk基金会和Nordisk研究基金会。

A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro.

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