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首页> 外文期刊>Endocrinology >Activation of Sox3 Gene by Thyroid Hormone in the Developing Adult Intestinal Stem Cell During Xenopus Metamorphosis
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Activation of Sox3 Gene by Thyroid Hormone in the Developing Adult Intestinal Stem Cell During Xenopus Metamorphosis

机译：爪蟾变态过程中正在发育的成人肠道干细胞中甲状腺激素对Sox3基因的激活

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摘要

The maturation of the intestine into the adult form involves the formation of adult stem cells in a thyroid hormone (T-3)-dependent process in vertebrates. In mammals, this takes place during postembryonic development, a period around birth when the T-3 level peaks. Due to the difficulty of manipulating late-stage, uterus-enclosed embryos, very little is known about the development of the adult intestinal stem cells. Interestingly, the remodeling of the intestine during the T-3-dependent amphibian metamorphosis mimics the maturation of mammalian intestine. Our earlier microarray studies in Xenopus laevis revealed that the transcription factor SRY (sex-determining region Y)-box 3 (Sox3), well known for its involvement in neural development, was upregulated in the intestinal epithelium during metamorphosis. Here, we show that Sox3 is highly and specifically expressed in the developing adult intestinal progenitor/stem cells. We further show that its induction by T-3 is independent of new protein synthesis, suggesting that Sox3 is directly activated by liganded T-3 receptor. Thus, T-3 activates Sox3 as one of the earliest changes in the epithelium, and Sox3 in turn may facilitate the dedifferentiation of the larval epithelial cells into adult stem cells.
机译：肠道成熟为成年形式涉及脊椎动物中甲状腺激素（T-3）依赖性过程中成年干细胞的形成。在哺乳动物中，这发生在胚胎后发育过程中，即出生时T-3水平达到峰值的时期。由于难以处理子宫封闭的晚期胚胎，对成年肠道干细胞的发育了解甚少。有趣的是，在依赖T-3的两栖动物变态过程中，肠道的重塑模仿了哺乳动物肠道的成熟。我们在非洲爪蟾的早期微阵列研究表明，转录因子SRY（性别决定区域Y）-box 3（Sox3）以其参与神经发育而闻名，在变态过程中其肠上皮表达上调。在这里，我们显示Sox3在正在发育的成年肠道祖细胞/干细胞中高度特异性地表达。我们进一步表明，其由T-3诱导与新蛋白合成无关，这表明Sox3被配体T-3受体直接激活。因此，T-3激活Sox3作为上皮细胞中最早的变化之一，而Sox3则可能促进幼虫上皮细胞去分化为成体干细胞。

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