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Endocrine Effects of Anorexia Nervosa

机译:神经性厌食症的内分泌作用

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摘要

A key feature of anorexia nervosa, a disease primarily psychiatric in origin, is chronic starvation, which results in profound neuroendocrine dysregulation, including hypogonadism, relative growth hormone resistance, and hypercortisolemia. A recent area of investigation is appetite hormone dysregulation. Whether such dysregulation is compensatory or plays a role in the pathophysiology of anorexia nervosa is incompletely understood. The primary therapy for anorexia remains psychiatric, and endocrine abnormalities tend to improve with weight restoration, although residual endocrine dysfunction can occur. In addition, therapies directed at specific complications have been a particular focus of research.
机译:神经性厌食症(一种主要起源于精神病的疾病)的一个关键特征是慢性饥饿,这会导致严重的神经内分泌失调,包括性腺机能减退,相对生长激素抵抗力和皮质醇过多症。最近的研究领域是食欲激素失调。这种失调是代偿性的还是在神经性厌食症的病理生理中起作用尚不清楚。厌食症的主要治疗方法仍然是精神病学,尽管可能会残留内分泌功能障碍,但随着体重的恢复,内分泌异常会改善。此外,针对特定并发症的疗法已成为研究的重点。

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