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首页> 外文期刊>Endocrinology and Metabolism Clinics of North America >Neuropsychiatric Findings in Cushing Syndrome and Exogenous Glucocorticoid Administration
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Neuropsychiatric Findings in Cushing Syndrome and Exogenous Glucocorticoid Administration

机译：库欣综合征和外源性糖皮质激素给药的神经精神病学发现

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摘要

This article reviews the neuropsychiatric presentations elicited by spontaneous hypercortisolism and exogenous supraphysiologic glucocorticoids. Patients with Cushing disease and syndrome develop a depressive syndrome: irritable and depressed mood, decreased libido, disrupted sleep and cognitive decrements. Exogenous short-term glucocorticoid administration may elicit a hypomanic syndrome with mood, sleep and cognitive disruptions. Treatment options are discussed. Brain imaging and neuropsychological studies indicate elevated cortisol and other glucocorticoids are especially deleterious to hippocampus and frontal lobe. The research findings also shed light on neuropsychiatric abnormalities in conditions that have substantial subgroups exhibiting elevated and dysregulated cortisol: aging, major depressive disorder and Alzheimer's disease.
机译：本文回顾了自发性高皮质醇过多症和外源性超生理性糖皮质激素引起的神经精神病学表现。库欣病和综合症患者会发展成抑郁症：情绪低落，情绪低落，性欲下降，睡眠中断和认知减退。短期外用糖皮质激素可能引起情绪低落，睡眠和认知障碍。讨论了治疗方案。脑部成像和神经心理学研究表明，皮质醇和其他糖皮质激素升高对海马和额叶尤其有害。该研究结果还揭示了在具有大量亚组表现出皮质醇升高和失调的实质性亚组的情况下的神经精神异常：衰老，重度抑郁症和阿尔茨海默氏病。

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