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Neuropsychiatric Manifestations of Thyroid Disease

机译:甲状腺疾病的神经精神病表现

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The interface between thyroid hormone action and neuropsychiatric function is intricate, and several mechanisms of thyroid hormone uptake into brain tissues, hormone activation, and influences on neurotransmitter generation have been identified. Symptoms of hypothyroidism are nonspecific, whereas those attributed to thyrotoxicosis may be more characteristic. Neuropsychiatric manifestations triggered by thyroid dysfunction likely respond well to reestablishment of the euthyroid state, although some patients have persistent complaints. The addition of LT3 to ongoing LT4 replacement has yet to be definitively shown to be advantageous. Treatment of euthyroid depression with LT3 in addition to antidepressant therapy lacks convincing evidence of superior outcomes.
机译:甲状腺激素的作用与神经精神功能之间的关系错综复杂,已经确定了甲状腺激素摄入脑组织,激素激活以及对神经递质生成的影响的几种机制。甲状腺功能减退的症状是非特异性的,而甲状腺毒症的症状可能更具特征。甲状腺功能异常引发的神经精神病学表现可能对甲状腺功能正常状态反应良好,尽管有些患者持续存在主诉。尚未确定将LT3添加到正在进行的LT4替换中是有利的。除抗抑郁治疗外,用LT3治疗甲状腺功能减退还缺乏令人信服的证据表明其疗效更高。

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