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Effects of Antipsychotic Medications on Appetite, Weight, and Insulin Resistance

机译:抗精神病药对食欲,体重和胰岛素抵抗的影响

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摘要

Although clozapine, olanzapine, and other atypical antipsychotic drugs (APDs) have fewer extrapyramidal side effects, they have serious metabolic side effects such as substantial weight gain, intra-abdominal obesity, and type 2 diabetes mellitus. Given that most patients with mental disorders face chronic, even life-long, treatment with APDs, the risks of weight gain/obesity and other metabolic symptoms are major considerations for APD maintenance treatment. This review focuses on the effects of APDs on weight gain, appetite, insulin resistance, and glucose dysregulation, and the relevant underlying mechanisms that may be help to prevent and treat metabolic side effects caused by APD therapy.
机译:虽然氯氮平,奥氮平和其他非典型抗精神病药(APD)具有较少的锥体外系副作用,但它们具有严重的代谢副作用,例如体重大量增加,腹腔内肥胖和2型糖尿病。鉴于大多数精神障碍患者面临APD的长期治疗,甚至终身治疗,因此体重增加/肥胖和其他代谢症状的风险是APD维持治疗的主要考虑因素。这篇综述着重于APD对体重增加,食欲,胰岛素抵抗和葡萄糖失调的影响,以及可能有助于预防和治疗APD治疗引起的代谢副作用的相关潜在机制。

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