Update on transplanting beta cells for reversing type 1 diabetes.

Robertson RP

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Update on transplanting beta cells for reversing type 1 diabetes.

机译：更新用于逆转1型糖尿病的beta细胞移植。

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Whole pancreas has been used successfully for transplantation for more than 30 years, and islets have been used reproducibly with success for 10 years; both procedures require drugs for immunosuppression. Success is judged by discontinuation of exogenous insulin-based treatment and maintenance of normal or nearly normal hemoglobin A1c. Successful pancreas transplantation has beneficial effects on retinopathy, nephropathy, neuropathy, macrovascular disease, and quality of life. Such findings are suggested for islet transplantation, but insufficient information is available to draw firm conclusions. Because of the paucity of annual pancreas donations, research for human beta cell surrogates is essential to provide a transplantation approach to therapy for a greater number of recipients.

机译：整个胰腺已成功用于移植超过30年，而胰岛已成功重复使用10年。两种方法都需要药物进行免疫抑制。通过中止基于外源胰岛素的治疗以及维持正常或接近正常的血红蛋白A1c来判断成功。成功的胰腺移植对视网膜病，肾病，神经病，大血管疾病和生活质量具有有益作用。这些发现建议用于胰岛移植，但尚无足够的信息得出明确的结论。由于每年很少捐赠胰腺，因此对人类β细胞替代物的研究对于为大量接受者提供治疗方法的移植方法至关重要。

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《Endocrinology and Metabolism Clinics of North America》 |2010年第3期|共13页
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Robertson RP;
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中图分类内分泌腺疾病及代谢病;
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1. Update on transplanting beta cells for reversing type 1 diabetes. [J] . Robertson RP Endocrinology and Metabolism Clinics of North America . 2010,第3期

机译：更新用于逆转1型糖尿病的beta细胞移植。
2. Incorporation of beta cell redifferentiation therapy into a lipoprivic strategy for reversing type 2 diabetes. [J] . McCarty M Medical hypotheses . 2002,第6期

机译：将β细胞再分化疗法纳入用于逆转2型糖尿病的吸脂策略。
3. Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes. [J] . Ghofaili KA, Fung M, Ao Z, Transplantation: Official Journal of the Transplantation Society . 2007,第1期

机译：艾塞那肽对1型糖尿病胰岛移植后β细胞功能的影响。
4. Cell-Type-Dependent Effect of Transforming Growth Factor-beta, a Major Cytokine in Breast Milk, on Human Immunodeficiency Virus Type 1 Infection of Mammary Epithelial MCF-7 Cells or Macrophages [C] . M. Moriuchi, H. Moriuchi International AIDS Conference . 2004

机译：转化生长因子-β，母乳中主要细胞因子的细胞型依赖性效应，对人免疫缺陷病毒1型感染乳腺上皮MCF-7细胞或巨噬细胞
5. An immunoisolating nanoporous alumina biocapsule for the encapsulation of beta cells to treat Type 1 diabetes. [D] . La Flamme, Kristen Elizabeth. 2007

机译：一种用于隔离β细胞以治疗1型糖尿病的免疫隔离纳米多孔氧化铝生物胶囊。
6. CACNA1E Variants Affect Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 3 [O] . Maddalena Trombetta, Sara Bonetti, MariaLinda Boselli, 2009

机译：CACNA1E变异影响新诊断的2型糖尿病患者的β细胞功能。维罗纳新诊断的2型糖尿病研究（VNDS）3
7. Islet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes. [O] . Subauste Angela, Gianani Roberto, Chang Annette M, 2014

机译：在临床诊断的2型糖尿病中，胰岛自身免疫可识别出胰腺β细胞功能受损，胰腺β细胞量明显减少和胰岛素抵抗的独特模式。

Update on transplanting beta cells for reversing type 1 diabetes.

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