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首页> 外文期刊>Electroanalysis >An Online Electrochemical System for Continuous Measurement of Glutamate with Signal Amplification by Enzymatic Substrate Cycling
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An Online Electrochemical System for Continuous Measurement of Glutamate with Signal Amplification by Enzymatic Substrate Cycling

机译：一种在线电化学系统，可通过酶底物循环连续测量谷氨酸并进行信号放大

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摘要

This study demonstrates a new online electrochemical system (OECS) for continuous monitoring of glutamate by efficiently integrating in vivo microdialysis and selective electrochemical detection with an enhanced sensitivity through enzymatic substrate cycling. We find that the involvement of enzymatic substrate cycling in the biosensing scheme remarkably increases the sensitivity of the OECS toward the measurements of glutamate. Moreover, the OECS demonstrated here is stable, reproducible, and selective and could thus be potentially useful for continuous monitoring of glutamate release in central nervous system. This study essentially offers a new approach to the continuous measurements of cerebral glutamate release, which is believed to find interesting applications in understanding the molecular basis underlying brain functions.
机译：这项研究展示了一种新型在线电化学系统（OECS），可通过有效整合体内微透析和选择性电化学检测，通过酶促底物循环提高灵敏度，从而连续监测谷氨酸。我们发现在生物传感方案中酶底物循环的参与显着增加了OECS对谷氨酸测量的敏感性。而且，这里证明的OECS是稳定的，可重复的和选择性的，因此可能对连续监测中枢神经系统中的谷氨酸释放有潜在的帮助。这项研究从本质上为连续测量脑内谷氨酸释放提供了一种新方法，据信该方法在理解脑功能的分子基础方面找到了有趣的应用。

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