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首页> 外文期刊>Electroanalysis >Simultaneous determination of ranitidine and metronidazole at glassy carbon electrode modified with single wall carbon nanotubes
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Simultaneous determination of ranitidine and metronidazole at glassy carbon electrode modified with single wall carbon nanotubes

机译：单壁碳纳米管修饰的玻碳电极上雷尼替丁和甲硝唑的同时测定

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摘要

Single-walled carbon nanotubes(SWCNTs) were dispersed into DMSO, and a SWCNTs-film coated glassy carbon electrode was achieved via evaporating the solvent. The results indicated that CNT modified glassy carbon electrode exhibited efficiently electrocatalytic reduction for ranitidine and metronidazole with relatively high sensitivity, stability and life time. Under conditions of cyclic voltarnmetry, the potential for reduction of selected analytes is lowered by approximately 150 mV and current is enhanced significantly (7 times) in comparison to the bare glassy carbon electrode. The electrocatalytic behavior is further exploited as a sensitive detection scheme for these analytes determinations by hydrodynamic amperometry. Under optimized condition in amperometric method the concentration calibration range, detection limit and sensitivity were about, 0.1 -200 mu M, detection limit (S/N= 3) 6.3 x 10(-8) mol L-1 and sensitivity 40 nA/ mu M for metronidazole and 0.3 -270 mu M 7.73 x 10(-8) mol L-1 and 25 nA/mu M for ranitidine. In addition, the ability of the modified electrode for simultaneous determination of ranitidine and metronidazole was evaluated. The proposed method was successfully applied to ranitidine and metronidazole determination in tablets. The analytical performance of this sensor has been evaluated for detection of these analytes in serum as a real sample.
机译：将单壁碳纳米管（SWCNTs）分散在DMSO中，并通过蒸发溶剂获得SWCNTs涂层的玻璃碳电极。结果表明，碳纳米管修饰的玻碳电极对雷尼替丁和甲硝唑具有较高的电催化还原性能，具有较高的灵敏度，稳定性和使用寿命。在循环伏安法的条件下，与裸露的玻璃碳电极相比，所选分析物的还原电势降低了约150 mV，电流显着提高（7倍）。电催化行为被进一步用作灵敏的检测方案，用于通过流体动力安培法测定这些分析物。在安培法的最佳条件下，浓度校准范围，检测限和灵敏度约为0.1 -200μM，检测限（S / N = 3）6.3 x 10（-8）mol L-1和灵敏度40 nA / mu M用于甲硝唑，0.3 -270μM，7.73 x 10（-8）mol L-1和25 nA /μM雷尼替丁。另外，评价了修饰电极同时测定雷尼替丁和甲硝唑的能力。该方法成功应用于雷尼替丁和甲硝唑片中的测定。已对该传感器的分析性能进行了评估，以检测血清中的这些分析物是否为真实样品。

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