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首页> 外文期刊>Electroanalysis >Sequential injection lab-on-valve procedure for the determination of amantadine using potentiometric methods
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Sequential injection lab-on-valve procedure for the determination of amantadine using potentiometric methods

机译：电位滴定法顺序进样的实验室测定金刚烷胺的实验室程序

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Amantadine potentiometric detectors were developed, evaluated and incorporated in a SIA-LOV manifold in order to accomplish the control of pharmaceutical formulations and urine. The electrodes incorporate a-cyclodextrin as ionophore, dibutyl phthalate or 2-fluorophenyl 2-nitrophenyl ether as plasticizers and potassium tetrakis[3,5-bis-(trifluoromethyl)phenyl]borate (KTFPB) as cationic additive. The slope increased from 61.2 to 63.8 mV decade(-1) and the practical limit of detection from 2.6 x 10(-6) mol L-1 to 2.5 x 10(-5) mol L-1 when the plasticizer was changed from 2-fluorophenyl 2-nitrophenyl ether to dibutyl phthalate. When incorporated in the flow-manifold the membranes composed by dibutyl phthalate or with 2-fluorophenyl 2-nitrophenyl ether presented slopes and a practical limit of detection of 69.8 mV decade(-1) and 1.5 x 10(-4) mol L-1 or 73.7 mV decade(-1) and 5.4 x 10(-5) mol L-1, respectively. The electrode presented stable responses for over a year, and were highly selective concerning the representative species of the two sample matrices assayed as interferents. Comparison of obtained results with those provided by reference methods and recovery assays, revealed adequate accuracy for control assays.
机译：开发了金刚烷胺电位检测器，对其进行了评估，并将其并入SIA-LOV歧管中，以实现对药物制剂和尿液的控制。电极包含作为离子载体的α-环糊精，作为增塑剂的邻苯二甲酸二丁酯或2-氟苯基2-硝基苯基醚和作为阳离子添加剂的四[3,5-双-（三氟甲基）苯基]硼酸钾（KTFPB）。当增塑剂从2变为2时，斜率从61.2 mV十倍（-1）增加到63.8 mV十倍（-1），实际检测极限从2.6 x 10（-6）mol L-1增加到2.5 x 10（-5）mol L-1 -氟苯基2-硝基苯基醚生成邻苯二甲酸二丁酯。当混入流动歧管中时，由邻苯二甲酸二丁酯或与2-氟苯基2-硝基苯基醚组成的膜呈现出斜率和实际检测极限，检测极限为69.8 mV十进位（-1）和1.5 x 10（-4）mol L-1或73.7 mV十进位（-1）和5.4 x 10（-5）mol L-1。电极在一年多的时间里表现出稳定的响应，并且对于作为干扰物的两种样品基质的代表性物种具有高度的选择性。将获得的结果与参考方法和回收率测定所提供的结果进行比较，发现对照测定具有足够的准确性。

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