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首页> 外文期刊>Bulletin of experimental biology and medicine >Recovery of impaired memory and c-fos gene expression in brains of amnestic animals in response to reminder stimulation
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Recovery of impaired memory and c-fos gene expression in brains of amnestic animals in response to reminder stimulation

机译：记忆记忆和大脑记忆c-fos基因表达的恢复，以提醒记忆刺激

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摘要

Possible mechanisms of recovery of the memory impaired during consolidation process were investigated. In mice, amnesia was induced by intraperitoneal cycloheximide (100 mg/kg) administration 20 min before exposure to tone signal combined with footshock (2 sec, 0.5 mA). Reminder by the footshock (2 sec, 0.5 mA) 24 h after the learning procedure resulted in recovery of impaired memory in amnestic animals up to the level of control animals. Analysis of c-Fos expression in response to reminder indicated increased number of c-Fospositive cells in prelimbic cortex in the animals with unaffected memory in comparison with corresponding parameter in amnestic animals. These findings are indicative of impairment in prelimbic cortex activity in experimental amnesia as well as for reminder ability to recover the memory impaired in that way.
机译：研究了在合并过程中受损的内存恢复的可能机制。在小鼠中，在暴露于声调信号并伴有休克（2秒，0.5 mA）之前20分钟，通过腹膜内给予环己酰亚胺（100 mg / kg）诱导失忆。学习程序后24小时，用触电提醒（2秒，0.5 mA），导致记忆删除的记忆力恢复到对照动物的水平。分析对催促反应的c-Fos表达，表明记忆力未受影响的动物与未记忆的动物相比，前肢皮质中c-Fos阳性细胞的数量增加。这些发现表明实验性健忘症的前肢皮质活动受损，并提示以这种方式恢复受损记忆的能力。

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