Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies

Demircigil BT.; Uslu B.; Ozkan Y.; Ozkan SA.; Senturk Z.

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Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies

机译：氨溴索的伏安氧化及其在药物和药物溶出度研究中的应用

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A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8 - 11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies. [References: 26]

机译：使用循环和微分脉冲伏安法在水溶液的pH范围1.8-11.0中对氨溴索在玻璃碳电极上的电化学进行了详细研究。该化合物在高正电势下不可逆地氧化，导致在正电势较小的情况下形成化学产物，该化学产物比母体化合物更容易被氧化。此外，提出了一种差分脉冲伏安法，用于测定不同药物制剂中的药物以及进行药物溶出度研究。 [参考：26]

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《Electroanalysis》 |2003年第3期|共5页
作者
Demircigil BT.; Uslu B.; Ozkan Y.; Ozkan SA.; Senturk Z.;
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正文语种 eng
中图分类电化学、电解、磁化学;
关键词
Ambroxol; Cyclic voltammetry; Differential pulse voltammetry; Glassy carbon electrode; Formulation analysis; Dissolution profile; Liquid-chromatographic determination; Human-plasma; Quantification; Hydrochloride; Bromhexine; Tablets; Fluids; Urine; Hplc;

机译：氨溴索;循环伏安法;差示脉冲伏安法;玻璃状碳电极;配方分析;溶出度;液相色谱法测定;人血浆;定量;氯化物;溴己定;片剂;流体;尿液;Hplc;

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1. Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies [J] . Demircigil BT., Uslu B., Ozkan Y., Electroanalysis . 2003,第3期

机译：氨溴索的伏安氧化及其在药物和药物溶出度研究中的应用
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3. Voltammetric Studies of Propylthiouracil at a Carbon-Paste Electrode Modified with Cobalt(II)-4-Chlorosalophen:Application to Voltammetric Determination in Pharmaceutical and Clinical Preparations [J] . Saeed Shahrokhian, Mohammad Jalal Jannat-Rezvani Mikrochimica Acta: An International Journal for Physical and Chemical Methods of Analysis . 2005,第1a2期

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7. Stability-Indicating HPTLC Determination of Ambroxol Hydrochloride in Bulk Drug and Pharmaceutical Dosage Form [O] . P. S. Jain 2010

机译：稳定性指示HPTLC盐酸氨溴氰咯基氧化物和药物剂型

Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies

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