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Highly-sensitive determination of 6-mercaptopurine and its metabolites by electrochemical reductive desorption measurements

机译：电化学还原解吸测量高灵敏度测定6-巯基嘌呤及其代谢物

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The electrochemical detection of 6-mercaputopurine (6-MP), which is one of the most well-known drugs of antimetabolites, and its analogues was studied. The presented method is based on chemisorption (accumulation)/desorption processes of drugs onto/from the An electrode surface. Using this method, we succeeded in detecting 6-MP even in very diluted solution (concentration of 6-MP: 1 x 10(-8) M). The lower detection limit of 6-MP was considerably improved compared with the previous HPLC studies by using our proposed system. Desorptive potentials of 6-MP-metabolites and its analogues were different from those of 6-MP. This provides the possibility of simultaneous detection of 6-MP and its typical metabolites.
机译：研究了6-巯基嘌呤（6-MP）的电化学检测方法，6-巯基嘌呤（6-MP）是最著名的抗代谢物之一，其类似物也得到了研究。提出的方法基于药物在电极表面上的化学吸附（累积）/解吸过程。使用这种方法，即使在非常稀释的溶液中（6-MP的浓度：1 x 10（-8）M），我们也成功检测了6-MP。通过使用我们提出的系统，与以前的HPLC研究相比，6-MP的检测下限有了很大的提高。 6-MP代谢物及其类似物的吸附潜力与6-MP的不同。这提供了同时检测6-MP及其典型代谢产物的可能性。

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