An amperometric immunosensor based on a gold nanoparticle-diazonium salt modified sensing interface for the detection of hba1c in human blood

Liu G.; Iyengar S.G.; Gooding J.J.

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An amperometric immunosensor based on a gold nanoparticle-diazonium salt modified sensing interface for the detection of hba1c in human blood

机译：基于金纳米颗粒-重氮盐修饰的传感界面的安培免疫传感器，用于检测人血中的hba1c

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摘要

An amperometric immunosensor for glycosylated hemoglobin (HbA1c) is reported. A glassy carbon electrode is modified with gold nanoparticles (AuNPs) bearing a ferrocene derivative and a glycosylated pentapeptide (GPP) as an epitope to which anti-HbA1c IgG can selectively bind. The rest of the electrode is passivated with an oligo(ethylene oxide) species to give the electrode resistant to nonspecific adsorption of proteins. Complexation of anti-HbA1c IgG with the surface bound epitope resulted in attenuation of the ferrocene electrochemistry. The immunosensor can detect HbA1c in the range of 4.6%-15.1% of total hemoglobin in human blood by a competitive inhibition assay.

机译：报告了一种用于糖基化血红蛋白（HbA1c）的安培免疫传感器。用载有二茂铁衍生物的金纳米颗粒（AuNPs）和糖基化五肽（GPP）作为表位可以修饰玻璃碳电极，抗HbA1c IgG可以选择性结合。电极的其余部分用低聚（环氧乙烷）物种钝化，以使电极能够抵抗蛋白质的非特异性吸附。抗HbA1c IgG与表面结合的表位的复合导致二茂铁电化学的减弱。通过竞争性抑制试验，该免疫传感器可以检测到人血中总血红蛋白的4.6％-15.1％的HbA1c。

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《Electroanalysis》 |2013年第4期|共7页
作者
Liu G.; Iyengar S.G.; Gooding J.J.;
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正文语种 eng
中图分类电化学、电解、磁化学;
关键词
Amperometric immunosensor; Aryl diazonium salts; Functionalized gold nanoparticles; HbA1c;

机译：安培免疫传感器;芳基重氮盐;功能化金纳米颗粒;HbA1c;

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1. An amperometric immunosensor based on a gold nanoparticle-diazonium salt modified sensing interface for the detection of hba1c in human blood [J] . Liu G., Iyengar S.G., Gooding J.J. Electroanalysis . 2013,第4期

机译：基于金纳米颗粒-重氮盐修饰的传感界面的安培免疫传感器，用于检测人血中的hba1c
2. Amperometric Immunosensor Based on Gold Nanoparticles/Fe _3O _4-FCNTs-CS Composite Film Functionalized Interface for Carbofuran Detection [J] . Sun X., Li Q., Wang X., Analytical Letters . 2012,第9a12期

机译：基于金纳米粒子/ Fe _3O _4-FCNTs-CS复合膜功能化界面的呋喃型安培传感器
3. Amperometric Immunosensor Based on Gold Nanoparticles/Fe₃O₄-FCNTs-CS Composite Film Functionalized Interface for Carbofuran Detection [J] . Xia Suna Qingqing Lia Professor Xiangyou Wanga* Shuyuan Dua Analytical Letters . 2012,第12期

机译：基于金纳米粒子/ Fe _{3 O _{4 -FCNTs-CS复合膜功能化界面的呋喃型安培传感器}}
4. A Micro Amperometric Immunosensor Based on Protein A/Gold nanoparticles/Self-assembled Monolayer-Modified Gold Electrode [C] . Institute of Electrical and Electronics Engineers International Conference on Nano/Micro Engineered and Molecular Systems . 2006

机译：基于蛋白质A /金纳米颗粒/自组装单层改性金电极的微凹凸免疫传感器
5. Development of amperometric immunosensors for protein biomarkers using single wall carbon nanotube forest and electrochemical detection of enzyme labels. [D] . Yu, Xin. 2006

机译：使用单壁碳纳米管森林和酶标记物的电化学检测技术开发用于蛋白质生物标记物的安培免疫传感器。
6. Amperometric Immunosensor Based on a Protein A/Deposited Gold Nanocrystals Modified Electrode for Carbofuran Detection [O] . Xia Sun, Ying Zhu, Xiangyou Wang 2011

机译：基于蛋白质A /沉积金纳米晶体修饰电极的安培型呋喃传感器的安培免疫传感器
7. Amperometric Immunosensor Based on a Protein A/Deposited Gold Nanocrystals Modified Electrode for Carbofuran Detection [O] . Sun, Xia, Zhu, Ying, Wang, Xiangyou 2011

机译：基于蛋白A /金纳米晶体修饰电极的安培型呋喃传感器的安培免疫传感器
8. Evaluation of a Ground Transient Electromagnetic Remote Sensing Method for the Deep Detection and Monitoring of Salt Water Interfaces [R] . Stewart, M. T. , Gay, M. C. 1983

机译：地面瞬变电磁遥感法在盐水界面深度探测与监测中的应用

An amperometric immunosensor based on a gold nanoparticle-diazonium salt modified sensing interface for the detection of hba1c in human blood

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