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Label-Free Sensing of Biomolecules with Field-Effect Devices for Clinical Applications

机译：用于临床应用的具有场效应设备的生物分子无标签传感

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摘要

Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.
机译：在提议的用于无分子检测生物分子的各种换能器概念中，半导体场效应器件（FED）是最有吸引力的平台之一。随着医学技术继续朝着基于生物标记物的诊断和治疗的方向发展，FED能够无标记，快速，实时地检测具有高特异性和敏感性的多种致病和生理相关分子的能力，为其在临床上的应用提供了非常有希望的前景。用于疾病的早期诊断和治疗的即时护理和个性化医学。提出的论文回顾了不同FED的最新进展和当前趋势，这些FED通过其固有的分子电荷对带电生物分子进行无标签，直接电学检测。作者主要致力于DNA杂交事件，抗体-抗原亲和反应以及临床相关生物分子（例如心脏和癌症生物标志物）的检测。

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