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首页> 外文期刊>Electroanalysis >Application of glassy carbon electrode modified with a bilayer of multiwalled carbon nanotube and polypyrrole doped with Nitrazine Yellow for voltammetric determination of naltrexone
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Application of glassy carbon electrode modified with a bilayer of multiwalled carbon nanotube and polypyrrole doped with Nitrazine Yellow for voltammetric determination of naltrexone

机译：多壁碳纳米管和硝氮黄掺杂的聚吡咯双层修饰玻碳电极在纳曲酮伏安测定中的应用。

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摘要

A new sensitive electrochemical sensor was fabricated based on a layer by layer process. In this process the glassy carbon electrode (GCE) is first coated by a thin film of multiwalled carbon nanotubes (MWCNTs). In the next step, the electropolymerization of pyrrole in the presence of Nitrazine Yellow (NY) as a dopant anion is performed on the surface of the MWCNTs precoated electrode. The electrochemical response characteristics of the modified electrode toward naltrexone (NTX) were studied by means of linear sweep voltammetry (LSV). A remarkable increase (~19 times) was observed in the anodic peak current of NTX on the surface of the modified electrode relative to the bare GCE. The effects of experimental parameters on the electrode response such as, drop size of the cast MWCNTs suspension, pH of the supporting electrolyte, accumulation conditions and the number of cycles in the electropolymerization process were investigated. Under the optimum conditions, the modified electrode showed a wide linear response to the concentration of NTX in the range of 4.0×10~(-8)-1×10~(-5)molL~(-1) with a detection limit of 12nmolL~(-1). The prepared sensor exhibited high sensitivity, stability and good reproducibility for the determination of NTX. This sensor was successfully applied for the accurate determination of trace amounts of NTX in pharmaceutical and clinical preparations.
机译：一种新的敏感电化学传感器是基于逐层工艺制造的。在此过程中，玻璃碳电极（GCE）首先被多层碳纳米管（MWCNT）薄膜覆盖。在下一步骤中，在预先涂覆的MWCNTs的表面上，在作为掺杂剂阴离子的硝基嗪黄（NY）存在下，吡咯进行电聚合。通过线性扫描伏安法（LSV）研究了修饰电极对纳曲酮（NTX）的电化学响应特性。相对于裸露的GCE，修饰电极表面上NTX的阳极峰值电流观察到了显着增加（〜19倍）。研究了实验参数对电极响应的影响，例如，铸造的MWCNTs悬浮液的液滴尺寸，支持电解质的pH，电聚合过程中的积累条件和循环次数。在最佳条件下，修饰电极对NTX浓度在4.0×10〜（-8）-1×10〜（-5）molL〜（-1）范围内表现出较宽的线性响应，检出限为12nmolL〜（-1）。所制备的传感器对NTX的测定具有很高的灵敏度，稳定性和可重复性。该传感器已成功应用于准确测定药物和临床制剂中痕量的NTX。

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