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首页> 外文期刊>Endothelium: Journal of endothelial cell research >Colombian study to assess the use of noninvasive determination of endothelium-mediated vasodilatation (CANDEV). Normal values and factors associated.
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Colombian study to assess the use of noninvasive determination of endothelium-mediated vasodilatation (CANDEV). Normal values and factors associated.

机译：哥伦比亚的一项研究评估了使用非侵入性方法测定内皮介导的血管舒张（CANDEV）。正常值和相关因素。

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The endothelium plays a critical role in vascular homeostasis. Recently, a noninvasive method has been developed to assess flow mediated vasodilatation of the brachial artery (FMD). This test is remarkably stable overtime but no clear set of normal values has been developed. The purposes of our study were to evaluate the accuracy and reproducibility and to identify a set of normal values of FMD. We included 253 normotensive healthy volunteers from three Colombian cities (mean age: 38.2 years; 33% were women). All subjects underwent ultrasound evaluation of endothelial and smooth muscle function. Flow mediated vessel diameter change was measured by two independent observers. The interobserver Lin's concordance correlation coefficient was 0.88% (95% CI: 0.82, 0.94) and there was no evidence of systematic difference between the two measurements (mean difference of -0.30% with limits of agreement of -4.48 to 3.87). Mean %FMD was 11.98% (95% CI: 11.36, 12.61), 13.32% (95% CI: 12.39, 14.25) in women and 11.32% (95% CI: 10.52, 12.13) in men. Subjects with no cardiovascular risk factors had a mean %FMD of 13.74% (95% CI: 13.14, 14.35), in contrast to a mean of only 7.40% (95% CI: 4.33, 9.91) in those with at least one risk factor. A %FMD cut point of 10.4 had a sensitivity of 71.2% and an specificity of 77.2% to identify subjects with at least one cardiovascular risk factor. Using this cut point, endothelial dysfunction was 3.13 times more frequent in subjects with than in subjects without cardiovascular risk factors (95% CI: 2.30, 4.25). In addition, obesity, smoking and hypercholesterolemia were the modifiable risk factors with largest independent significant reduction effects on %FMD. FMD measurements can be made with high accuracy and precision, and a cut point of 10.4% is useful to discriminate between subjects with and without cardiovascular risk factors, and can be recommended as a screening test for the detection of patients at risk of CVD.
机译：内皮在血管稳态中起关键作用。最近，已开发出一种非侵入性方法来评估肱动脉（FMD）的血流介导的血管舒张。该测试在长时间内非常稳定，但是尚无明确的正常值设置。我们研究的目的是评估准确性和可重复性，并确定FMD的一组正常值。我们纳入了来自三个哥伦比亚城市的253名血压正常的健康志愿者（平均年龄：38.2岁; 33％是女性）。所有受试者均接受超声评估内皮和平滑肌功能。流量介导的血管直径变化是由两个独立的观察者测量的。观察者林之间的一致性相关系数为0.88％（95％CI：0.82，0.94），并且没有证据表明这两次测量之间存在系统性差异（均值差异为-0.30％，一致性范围为-4.48至3.87）。女性的平均％FMD为11.98％（95％CI：11.36，12.61），13.32％（95％CI：12.39，14.25）和男性的11.32％（95％CI：10.52，12.13）。没有心血管危险因素的受试者的平均％FMD为13.74％（95％CI：13.14，14.35），而具有至少一种危险因素的受试者的平均％FMD为7.40％（95％CI：4.33，9.91） 。 ％FMD临界点为10.4，具有71.2％的敏感性和77.2％的特异性，可确定患有至少一种心血管危险因素的受试者。使用该切点，有无心血管危险因素的受试者的内皮功能障碍发生率是无心血管危险因素的受试者的3.13倍（95％CI：2.30，4.25）。此外，肥胖，吸烟和高胆固醇血症是可改变的危险因素，其对％FMD的最大独立显着降低作用。 FMD测量可以高精度，高精确度进行，并且10.4％的分界点可用于区分有无心血管危险因素的受试者，并建议将其作为筛查测试来检测有CVD危险的患者。

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