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首页> 外文期刊>Endothelium: Journal of endothelial cell research >Noninvasive assessment of endothelial activity in patients with peripheral arterial disease and cardiovascular risk factors.
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Noninvasive assessment of endothelial activity in patients with peripheral arterial disease and cardiovascular risk factors.

机译：非侵入性评估外周动脉疾病和心血管危险因素患者的血管内皮活性。

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摘要

Microvascular endothelial activity (EA) after stimulation with iontophoretically administered acetylcholine was evaluated using laser Doppler fluxmetery (LDF) and calibrated photoplethysmography (c-PPG) in normal patients and patients with peripheral artery disease (PAD). The patients included 79 non-PAD subjects and 51 patients with PAD. Upper and lower extremity EA was examined using LDF and c-PPG after acetylcholine iontophoresis for 10 min. Sensitivity and specificity were assessed using integrated area under response curve. In non-PAD patients, the EA by LDF in the upper extremity was significantly lower in the older patients compared to the younger patients. Conversely, EA by LDF detected no significant difference between these groups in the lower extremity.With c-PPG, the EA was slightly reduced in the upper but not in the lower extremity in older patients. Comparing PAD patients to the older patients, there was a significantly lower EA response in the upper and lower extremities by LDF. Likewise, c-PPG detected a highly significantly reduced EA in the upper and lower extremities for PAD patients. These results indicated that using a noninvasive technique to determine EA, there were significant differences in the EA response to acetylcholine between those with PAD and normal patients over the age of 50. Importantly, the EA response was reduced in the upper and lower extremities, indicating systemic disease of the endothelium in PAD patients.
机译：使用激光多普勒通量计（LDF）和标定的光电容积描记法（c-PPG）对正常患者和外周动脉疾病（PAD）患者进行离子电渗入的乙酰胆碱刺激后的微血管内皮活性（EA）进行评估。这些患者包括79名非PAD受试者和51名PAD患者。乙酰胆碱离子电渗疗法10分钟后，使用LDF和c-PPG检查上下肢EA。使用反应曲线下的积分面积评估敏感性和特异性。在非PAD患者中，老年患者的LDF在上肢的EA明显低于年轻患者。相反，LDF的EA在下肢中没有发现这些组之间的显着差异。使用c-PPG，老年患者的EA在上肢中略有降低，但在下肢中没有降低。比较PAD患者和老年患者，LDF在上肢和下肢的EA反应显着降低。同样，c-PPG在PAD患者的上肢和下肢检测到EA明显降低。这些结果表明，使用无创技术确定EA时，PAD患者和50岁以上的正常患者对乙酰胆碱的EA反应存在显着差异。重要的是，上肢和下肢的EA反应有所降低，表明PAD患者的内皮系统性疾病。

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