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首页> 外文期刊>Endothelium: Journal of endothelial cell research >Early effects of treatment with nebivolol and quinapril on endothelial function in patients with hypertension.
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Early effects of treatment with nebivolol and quinapril on endothelial function in patients with hypertension.

机译：奈比洛尔和奎那普利治疗对高血压患者内皮功能的早期影响。

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摘要

The objective of the present study was to compare the early effects of treatment with nebivolol and quinapril on the endothelial function in hypertensive patients. A total of 54 hypertensive patients was enrolled in the present study. One of the groups (n = 27) received quinapril 20 mg/day, and the other group (n = 27) received nebivolol 5 mg/day for a period of 4 weeks. The endothelial dysfunction was assessed using FMD (flow-mediated vasodilation) of the brachial arteries. The baseline characteristics of both groups were similar in age, gender, left venticular ejection fraction, left ventricular mass index, and body mass index. No significant difference was also found between the groups in the distribution of atherosclerotic risk factors as well as other echocardiographic, demographic, and biochemical measurements. Although the reduction of diastolic blood pressure was more pronounced in the nebivolol group after a 4-week treatment, the change in the systolic blood pressure was found to be similar inboth treatment arms. Although a statistically nonsignificant increase was observed in flow-mediated vasodilation in the quinapril group (4.77% +/- 3.92%, 5.60% +/- 6.18%; p = .587), the increase in the post-treatment FMD was statistically significant in the nebivolol group (3.78% +/- 4.25%, 8.56% +/- 6.39%; p = .002). A significant change was observed in the resistive index value following flow-mediated vasodilation for both groups after treatment (p = .043; p = .027), whereas the change in the value of flow volume was significant only in the nebivolol group (p = .019).
机译：本研究的目的是比较奈比洛尔和奎那普利对高血压患者内皮功能的早期治疗作用。本研究共纳入54名高血压患者。一组（n = 27）接受喹那普利20 mg /天，另一组（n = 27）接受奈必洛尔5 mg /天，持续4周。使用肱动脉的FMD（流量介导的血管舒张）评估内皮功能障碍。两组的基线特征在年龄，性别，左心室射血分数，左心室质量指数和体重指数方面相似。两组之间在动脉粥样硬化危险因素的分布以及其他超声心动图，人口统计学和生化测量方面也没有发现显着差异。尽管奈比洛尔组经过4周的治疗后舒张压的降低更为明显，但发现两组的收缩压变化相似。尽管奎纳普利组的血流介导的血管舒张作用在统计学上无统计学意义的增加（4.77％+/- 3.92％，5.60％+/- 6.18％; p = .587），但治疗后FMD的增加在统计学上是显着的奈比洛尔组（3.78％+/- 4.25％，8.56％+/- 6.39％; p = 0.002）。两组在治疗后，血流介导的血管舒张后的电阻指数值均发生了显着变化（p = .043; p = .027），而仅奈必洛尔组的血流量变化显着（p = .019）。

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