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首页> 外文期刊>Endothelium: Journal of endothelial cell research >The effects of vinblastine on endothelial cells.
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The effects of vinblastine on endothelial cells.

机译：长春碱对内皮细胞的影响。

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The development of drug-eluting stents to combat the problem of in-stent restenosis has revolutionized interventional cardiology. However, concerns have emerged about the risk of late angiographic stent thromboses associated with drug-eluting stents. It has been shown that noncytotoxic concentrations of paclitaxel exert an antiangiogenic effect, suggesting that paclitaxel and similar agents may inhibit key cellular functions in a threshold-independent manner. In this study, the effect of vinblastine, an antimitotic drug, on endothelial cells is analyzed. It is investigated whether noncytotoxic concentrations of the drug could exert an antirestenotic effect. The change in levels of cell proliferation, activity, and viability in human umbilical vein endothelial cells was measured at a range of concentrations and over a number of time points. Also, the level of apoptotic activity in response to vinblastine was analyzed. This study shows that the concentration of vinblastine most appropriate in restenosis treatment would be between 0.1 and 1 nM. At this concentration, vinblastine exerts a distinct biological effect without causing an increase in apoptotic activity. These results emphasize the importance of finding an appropriate concentration window in order to minimize the risk of delayed endothelialization and thrombosis.
机译：药物洗脱支架的开发，以解决支架内再狭窄问题，彻底改变了介入心脏病学。然而，人们担心与药物洗脱支架相关的晚期血管造影支架血栓形成的风险。已经显示非细胞毒性浓度的紫杉醇发挥抗血管生成作用，表明紫杉醇和类似药物可以以阈值独立的方式抑制关键的细胞功能。在这项研究中，分析了一种抗有丝分裂药物长春碱对内皮细胞的作用。研究了该药物的非细胞毒性浓度是否可以发挥抗再狭窄作用。在一定浓度范围内和多个时间点测量人脐静脉内皮细胞中细胞增殖，活性和活力水平的变化。此外，分析了响应长春碱的凋亡活性水平。这项研究表明，再狭窄治疗中最合适的长春碱浓度在0.1到1 nM之间。在此浓度下，长春碱具有独特的生物学作用，而不会引起凋亡活性的增加。这些结果强调了寻找合适浓度窗口的重要性，以使延迟内皮化和血栓形成的风险最小化。

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