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首页> 外文期刊>Bulletin of experimental biology and medicine >Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs
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Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs

机译：达拉根对非甾体类抗炎药治疗胃病的胃保护作用

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摘要

We studied the effect of dalargin and its analogue [Dala]2- leu-enkephalin on the gastric mucosa in indomethacin-receiving animals. Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues. Dalargin significantly decreased the area of erosive and ulcerative lesions, had a normalizing effect on proliferation of epithelial cells, and reduced the degree of oxidative stress. Administration of [Dala]2- leu-enkephalin did not improve the state of the gastric mucosa.
机译：我们研究了达拉根及其类似物[Dala] 2-leu-脑啡肽对吲哚美辛接受动物胃黏膜的影响。消炎痛治疗后，胃粘膜受到严重损伤，上皮的增殖活性降低，并刺激了胃组织的自由基过程。达拉根显着减少了侵蚀性和溃疡性病变的面积，对上皮细胞的增殖具有正常化作用，并降低了氧化应激的程度。施用Dala 2-leu-脑啡肽不能改善胃粘膜的状态。

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