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首页> 外文期刊>Endocrine Research >Oxidized products of linoleic acid stimulate adrenal steroidogenesis.
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Oxidized products of linoleic acid stimulate adrenal steroidogenesis.

机译：亚油酸的氧化产物刺激肾上腺类固醇生成。

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摘要

Adrenal steroidogenesis is under complex control, and clinical observations suggest that not all regulators have been identified. We postulated that fatty acid oxidation products found in the diet or formed in the body could affect steroidogenesis. Linoleic acid is a prominent constituent of animal fat and is readily oxidized. We found that several products of linoleic acid oxidation affect production of aldosterone and corticosterone by isolated cells from rat adrenals. We characterized one linoleic acid derivative by gas chromatography/mass spectrometry. It is 12,13-epoxy-9-oxo-10(trans)-octadecenoic acid ("EKODE"). At concentrations between 1 and 30 microM, EKODE stimulated production of aldosterone by zona glomerulosa cells, but at concentrations above 50 microM, it was inhibitory. In zona fasciculata cells, EKODE stimulated corticosterone production at concentrations of 5 microM or greater, and there was no evidence of inhibition at high concentrations. Stimulation of steroidogenesis was observed after 15 min of incubation and continued for at least 2 hrs. The potential relevance of our findings to the hypertension of obesity is discussed.
机译：肾上腺类固醇生成处于复杂的控制之下，临床观察表明并非所有调节因子都已被鉴定。我们推测在饮食中发现或在体内形成的脂肪酸氧化产物可能会影响类固醇生成。亚油酸是动物脂肪的重要组成部分，容易被氧化。我们发现亚油酸氧化的几种产物会影响从大鼠肾上腺分离的细胞产生醛固酮和皮质酮的能力。我们通过气相色谱/质谱法表征了一种亚油酸衍生物。它是12,13-环氧-9-氧代-10（反式）-十八烯酸（“ EKODE”）。在1至30 microM的浓度下，EKODE刺激了肾小球带状细胞产生醛固酮，但在高于50 microM的浓度下，它具有抑制作用。在透明带状细胞中，EKODE在浓度为5 microM或更高时刺激了皮质酮的产生，在高浓度下没有抑制作用的证据。温育15分钟后观察到类固醇生成的刺激，并持续至少2小时。讨论了我们的发现与肥胖高血压的潜在相关性。

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