Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH.

Agarwal AK

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Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH.

机译：皮质醇代谢和内脏肥胖：11β-羟基类固醇脱氢酶I型酶和减少的辅因子NADPH的作用。

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Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co-factor, NADPH, could exacerbate the enzymatic activity.

机译：遗传和环境等多种因素在肥胖和代谢综合征的发展中起作用。过度表达11β-羟基类固醇脱氢酶（11beta-HSD）的转基因小鼠发展为内脏肥胖症。但是，尚不清楚普遍表达的11β-HSD1酶如何对脂肪组织产生如此大的影响，以至于会导致肥胖。在这篇评论中，我们探讨了减少辅因子NADPH的细胞内可用性增加可能加剧酶促活性的可能性。

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《Endocrine Research》 |2003年第4期|共8页
作者
Agarwal AK;
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正文语种 eng
中图分类基础医学;
关键词
Obesity; Role; NADP; Hydroxysteroid Dehydrogenases; Enzymes; 肥胖症; 角色; 羟甾类脱氢酶类; 酶类;

机译：Obesity;Role;NADP;Hydroxysteroid Dehydrogenases;Enzymes;肥胖症;角色;羟甾类脱氢酶类;酶类;

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1. Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH. [J] . Agarwal AK Endocrine Research . 2003,第4期

机译：皮质醇代谢和内脏肥胖：11β-羟基类固醇脱氢酶I型酶和减少的辅因子NADPH的作用。
2. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients. [J] . Baudrand R, Carvajal CA, Riquelme A, Obesity surgery . 2010,第1期

机译：肝脏和内脏脂肪组织中11β-羟类固醇脱氢酶1型的过表达与病态肥胖患者的代谢异常有关。
3. Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo. [J] . De-Sousa-Peixoto RA, Turban S, Battle JH, Endocrinology . 2008,第4期

机译：1型前脂肪细胞11β-羟基类固醇脱氢酶是一种酮还原酶，可在体内引起饮食引起的内脏肥胖。
4. Compared expression of the 11beta-hydroxysteroid dehydrogenase type 1 in the brain of high energy diet induced obese rats [C] . Forte M., lachetta G., Prisco M., International Congress of Comparative Endocrinology . 2014

机译：在高能量饮食诱导肥胖大鼠脑中脑脑脑脑外培养型1型表达1
5. Estrogen regulation of the pregnant baboon placental 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-catalyzed metabolism of cortisol and cortisone and its effect on the development of the fetal hypothalamic-pituitary-adrenal axis. [D] . Davies, William Adair. 2001

机译：孕妇狒狒胎盘11β-羟类固醇脱氢酶（11β-HSD）催化的皮质醇和可的松的代谢及其对胎儿下丘脑-垂体-肾上腺轴发育的影响。
6. Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats [O] . Vara Prasad SS Sakamuri, Prashanth Ananthathmakula, Giridharan Nappan Veettil, 2011

机译：维生素A减少肥胖症患者糖皮质激素的受体前体扩增：维生素A对WNIN / Ob肥胖大鼠肝脏和内脏脂肪中11β-羟类固醇脱氢酶1型活性的影响
7. Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats [O] . Vara Prasad SS Sakamuri, Prashanth Ananthathmakula, Giridharan Nappan Veettil, 2011

机译：维生素A减少肥胖症患者糖皮质激素的受体前体扩增：维生素A对WNIN / Ob肥胖大鼠肝脏和内脏脂肪中11β-羟类固醇脱氢酶1型活性的影响

Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH.

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