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首页> 外文期刊>Endocrine Research >F18-fluorodeoxyglucose positron emission tomography in detecting metastatic papillary thyroid carcinoma with elevated human serum thyroglobulin levels but negative I-131 whole body scan.
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F18-fluorodeoxyglucose positron emission tomography in detecting metastatic papillary thyroid carcinoma with elevated human serum thyroglobulin levels but negative I-131 whole body scan.

机译：F18-氟脱氧葡萄糖正电子发射断层扫描可检测转移性甲状腺乳头状癌，其人血清甲状腺球蛋白水平升高，但I-131全身扫描阴性。

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摘要

Papillary carcinomas are the most common thyroid malignancies. They invade the regional lymphatics and metastasize frequently to local lymph nodes in the neck. Distant metastasis, generally to the lungs, is also common. METHODS: The aim of this study is to evaluate the effectiveness of F18-fluorodeoxyglucose (FDG) positron emission tomography (PET) to detect metastatic lesions in patients with papillary thyroid carcinomas (PTC) after nearly total thyroidectomy and I-131 treatments who present with elevated human serum thyroglobulin (hTg) levels but negative 1-131 whole body scan (WBS). Twenty patients with PTC who underwent nearly total thyroidectomy and radioiodine treatments were included in this study. RESULTS: All of the 20 patients had negative I-131 WBS results and elevated hTg levels (hTg > or = 2.0 microIU/mL) under thyroid-stimulating hormone (TSH) stimulation (TSH > or = 30 microIU/mL). CONCLUSIONS: FDG-PET was perform to detect metastatic lesions. F18-fluorodeoxyglucose-PET could detect hypermetabolic lesions in 17 patients but failed to demonstrate miliary pulmonary metastases in two patients. No definite lesion was found in FDG-PET, x-ray chest computed tomography (CT) and other imaging studies of the remaining one patient This study showed that FDG-PET is a useful tool in detecting metastatic lesions in PTC with elevated hTg but negative I-131 WBS. However, miliary lung metastases may be missed in FDG-PET. In this circumstance, chest CT should be included in the follow-up protocol.
机译：乳头状癌是最常见的甲状腺恶性肿瘤。它们侵入局部淋巴管并经常转移至颈部的局部淋巴结。通常到肺的远处转移也是常见的。方法：本研究的目的是评估F18-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）在几乎完全进行甲状腺切除术和I-131治疗后出现乳头状甲状腺癌（PTC）患者中检测转移灶的有效性。人血清甲状腺球蛋白（hTg）水平升高，但1-131全身扫描（WBS）阴性。这项研究包括20例接受了几乎完全甲状腺切除术和放射性碘治疗的PTC患者。结果：在甲状腺刺激激素（TSH）刺激下（TSH>或= 30 microIU / mL），所有20例患者的I-131 WBS结果均为阴性，hTg水平升高（hTg>或= 2.0 microIU / mL）。结论：FDG-PET用于检测转移性病变。 F18-氟脱氧葡萄糖-PET可以检测17例患者的代谢异常，但未能显示2例患者发生粟粒性肺转移。在FDG-PET，X射线胸部计算机断层扫描（CT）和其他对剩余一名患者的影像学研究中未发现明确的病变。这项研究表明，FDG-PET是检测hTg升高但阴性的PTC转移性病变的有用工具。 I-131 WBS。但是，FDG-PET中可能错过了粟粒性肺转移。在这种情况下，随访中应包括胸部CT。

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