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首页> 外文期刊>Environmental health perspectives. >Out-of-hospital cardiac arrest and airborne fine particulate matter: a case-crossover analysis of emergency medical services data in Indianapolis, Indiana.
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Out-of-hospital cardiac arrest and airborne fine particulate matter: a case-crossover analysis of emergency medical services data in Indianapolis, Indiana.

机译：院外心脏骤停和空气中的细颗粒物：印第安纳州印第安纳波利斯的紧急医疗服务数据的病例交叉分析。

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BACKGROUND: Previous studies have found particulate matter (PM) < 2.5 microm in aerodynamic diameter (PM2.5) associated with heart disease mortality. Although rapid effects of PM2.5 exposure on the cardiovascular system have been proposed, few studies have investigated the effect of short-term exposures on out-of-hospital cardiac arrest (OHCA). OBJECTIVES: We aimed to determine whether short-term PM2.5 exposures increased the risk of OHCA and whether risk depended on subject characteristics or presenting heart rhythm. METHODS: A case-crossover analysis determined hazard ratios (HRs) for OHCAs logged by emergency medical systems (EMS) versus hourly and daily PM2.5 exposures at the time of the OHCA and for daily and hourly periods before it. RESULTS: For all OHCAs (n = 1,374), exposures on the day of the arrest or 1-3 days before arrest had no significant effect on the incidence of OHCA. For cardiac arrests witnessed by bystanders (n = 511), OHCA risk significantly increased with PM2.5 exposure during the hour of the arrest (HR for a 10-microg/m3 increase in PM2.5 exposure = 1.12; 95% confidence interval, 1.01-1.25). For the subsets of subjects who were white, 60-75 years of age, or presented with asystole, OHCA risk significantly increased with PM2.5 during the hour of the arrest (HRs for a 10-microg/m3 increase in PM2.5 = 1.18, 1.25, or 1.22, respectively; p < 0.05). HR generally decreased as the time lag between PM2.5 exposure and OHCA increased. CONCLUSION: The results suggest an acute effect of short-term PM2.5 exposure in precipitating OHCAs, and a need to investigate further the role of subject factors in the effects of PM on the risk of OHCA.
机译：背景：先前的研究发现，空气动力学直径（PM2.5）中的颗粒物（PM）<2.5微米与心脏病死亡率相关。尽管已经提出了PM2.5暴露对心血管系统的快速影响，但很少有研究调查短期暴露对院外心脏骤停（OHCA）的影响。目的：我们旨在确定短期PM2.5暴露是否会增加OHCA的风险，以及该风险是否取决于受试者的特征或表现出的心律。方法：病例交叉分析确定了由紧急医疗系统（EMS）记录的OHCA的危险比（HRs）与OHCA时以及在其发生前的每天和每小时的PM2.5暴露量的对比。结果：对于所有OHCA（n = 1,374），在逮捕当天或逮捕前1-3天暴露对OHCA的发生率没有显着影响。对于旁观者所见的心脏骤停（n = 511），在停搏期间，PM2.5暴露会导致OHCA风险显着增加（HR对PM2.5暴露的增加为10 microg / m3 = 1.12; 95％的置信区间， 1.01-1.25）。对于白人，60-75岁或出现心搏停止的受试者的子集，在逮捕期间，PM2.5会使OHCA风险显着增加（PM2.5升高10微克/立方米，HRs =分别为1.18、1.25或1.22; p <0.05）。随着PM2.5暴露与OHCA之间的时间间隔增加，HR通常会降低。结论：结果提示短期暴露于PM2.5对OHCA的沉淀具有急性作用，并且有必要进一步研究主体因素在PM对OHCA风险的影响中的作用。

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