The nuclear RNA surveillance machinery: The link between ncRNAs and genome structure in budding yeast?

Jonathan Houseley; David Tollervey

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The nuclear RNA surveillance machinery: The link between ncRNAs and genome structure in budding yeast?

机译：核RNA监测机制：芽孢酵母中ncRNA与基因组结构之间的联系？

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The TRAMP polyadenylation complexes have well-established functions in RNA surveillance, stimulating degradation by the 3' to 5' exonuclease activity of the exosome on a wide range of nuclear RNAs and RNA-protein complexes. Known targets include some of the non-protein coding RNA transcripts (ncRNAs), which are apparently widely transcribed from yeast and mammalian genomes. We will discuss potential mechanisms of TRAMP recruitment and exosome activation during RNA surveillance and degradation. Less well-understood observations link both the TRAMP and exosome complexes to chromatin structure and DNA repair, and we will speculate on the potential significance of these activities.

机译：TRAMP聚腺苷酸化复合物在RNA监测中具有公认的功能，可通过外泌体在多种核RNA和RNA-蛋白质复合物中的3'至5'核酸外切酶活性来刺激降解。已知的靶标包括一些非蛋白质编码的RNA转录本（ncRNA），显然可以从酵母和哺乳动物基因组中广泛转录。我们将讨论RNA监视和降解过程中TRAMP募集和外来体激活的潜在机制。尚不为人所知的观察结果将TRAMP和外泌体复合物与染色质结构和DNA修复联系在一起，我们将推测这些活性的潜在重要性。

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《Biochimica et Biophysica Acta. Gene Regulatory Mechanisms》 |2008年第4期|共8页
作者
Jonathan Houseley; David Tollervey;
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原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
Poly(A) polymerase; TRAMP; ncRNA; Chromatin; RNA surveillance;

机译：Poly（A）聚合酶;TRAMP;ncRNA;染色质;RNA监测;

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1. The nuclear RNA surveillance machinery: The link between ncRNAs and genome structure in budding yeast? [J] . Jonathan Houseley, David Tollervey Biochimica et Biophysica Acta. Gene Regulatory Mechanisms . 2008,第4期

机译：核RNA监测机制：芽孢酵母中ncRNA与基因组结构之间的联系？
2. Nuclear Export Receptor Xpo1/Crm1 Is Physically and Functionally Linked to the Spindle Pole Body in Budding Yeast [J] . Anja Neuber, Jacqueline Franke, Angelika Wittstruck, Molecular and Cellular Biology . 2008,第17期

机译：核出口受体Xpo1 / Crm1物理和功能上链接到芽酵母中的纺锤体。
3. Distinct modes of TATA box utilization by the RNA polymerase III transcription machineries from budding yeast and higher plants [J] . Dieci Giorgio, Yukawa Yasushi, Alzapiedi Mircko, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2006,第Null期

机译：芽苗和高等植物中RNA聚合酶III转录机制利用TATA盒的不同模式
4. CONSTRUCTION OF MOLECULAR CATCHERS FOR SHORT NON-CODING RNA (SHORT NCRNA) USING MUTANT RIBONUCLEASE 1-AND PAZ DOMAIN-DISPLAYING YEASTS [C] . Natsuko Miura, Eri Hayashi, Hironobu Morisaka, The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛） . 2009

机译：用突变核糖核酸酶1-和PAZ域显示酶构建短链非编码RNA分子分子
5. Fusion of inverted repeats leads to formation of dicentric chromosomes that cause genome instability in budding yeast. [D] . Kaochar, Salma. 2010

机译：反向重复序列的融合导致形成双着丝粒染色体，从而导致发芽酵母中的基因组不稳定。
6. Nuclear Export Receptor Xpo1/Crm1 Is Physically and Functionally Linked to the Spindle Pole Body in Budding Yeast [O] . Anja Neuber, Jacqueline Franke, Angelika Wittstruck, 2008

机译：核出口受体Xpo1 / Crm1物理和功能上链接到芽酵母中的纺锤体。
7. Nuclear Export Receptor Xpo1/Crm1 Is Physically and Functionally Linked to the Spindle Pole Body in Budding Yeast▿ † [O] . Neuber, Anja, Franke, Jacqueline, Wittstruck, Angelika, 2008

机译：核出口受体Xpo1 / Crm1在萌芽酵母中在物理上和功能上都与纺锤极体相连▿†

The nuclear RNA surveillance machinery: The link between ncRNAs and genome structure in budding yeast?

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