...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Equine Veterinary Education >The role of oral disease-modifying agents glucosamine and chondroitin sulphate in the management of equine degenerative joint disease.
【24h】

The role of oral disease-modifying agents glucosamine and chondroitin sulphate in the management of equine degenerative joint disease.

机译：口服疾病调节剂氨基葡萄糖和硫酸软骨素在马变性关节疾病的治疗中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Degenerative joint disease (DJD) is a disease of synovial joints associated with the development of chronic pathological cartilage damage and secondary osseous remodelling with periarticular osteophyte formation. The associated articular soft tissues and subchondral bone are progressively involved as disease manifests and are the primary sites demonstrating clinical signs which include inflammation, swelling, reduced mobility and articular pain. The cartilage damage occurring in early DJD should not be regarded as a passive loss of cartilage tissue but rather as a dynamic disturbance of the metabolism of chondrocytes, the cells responsible for cartilage matrix maintenance and integrity. Such disturbances produce an overall catabolic state within the tissue, resulting in a net loss of collagen and proteoglycans, the main components of cartilage matrix. As the arthritic condition develops, radiological evidence of joint degeneration, which occurs at a relatively late stage in the disease process and includes joint narrowing (cartilage loss) and periarticular osteophyte formation, becomes apparent.
机译：退行性关节疾病（DJD）是一种滑膜关节疾病，与慢性病理性软骨损伤的发展以及继发性骨重塑以及关节周围骨赘的形成有关。相关的关节软组织和软骨下骨随着疾病的进展而逐渐累及，并且是显示临床症状的主要部位，这些临床症状包括炎症，肿胀，活动性降低和关节痛。 DJD早期发生的软骨损伤不应被视为软骨组织的被动损失，而应被视为软骨细胞代谢的动态障碍，软骨细胞负责软骨基质的维持和完整性。这种干扰会在组织内产生整体分解代谢状态，导致胶原蛋白和蛋白聚糖（软骨基质的主要成分）的净损失。随着关节炎病情的发展，明显出现关节退变的放射学证据，这种疾病发生在疾病过程的相对晚期，包括关节变窄（软骨丧失）和关节周围骨赘的形成。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号