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首页> 外文期刊>Equine Veterinary Education >Evidence-based Clinical Question: Evidence for dimethyl sulphoxide (DMSO) use in horses. Part 2: DMSO as a parenteral anti-inflammatory agent and as a pharmacological carrier
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Evidence-based Clinical Question: Evidence for dimethyl sulphoxide (DMSO) use in horses. Part 2: DMSO as a parenteral anti-inflammatory agent and as a pharmacological carrier

机译：基于证据的临床问题：有关在马中使用二甲亚砜（DMSO）的证据。第2部分：DMSO作为肠胃外抗炎药和药理载体

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The evidence for the use of dimethyl sulphoxide as a topical anti-inflammatory agent, and for intra-articular use, was examined in Part 1 (Schleining and Reinertson 2007). Part 2 examines the use of DMSO as a parenteral anti-inflammatory agent, and asa pharmacological carrier. Parenteral anti-inflammatory: The observation of the ability of DMSO to scavenge oxygen-derived free radicals has lead to an interest in its use to prevent reperfusion injury following ischaemia to the gastrointestinal tract.Many of the studies in this area utilise either a low-flow or complete arterial and venous occlusion model of either the small or large intestine. The first study was published in 1989 and included 18 ponies that underwent 1 h of jejunal ischaemia followed by 1 h of reperfusion. The ponies in the DMSO group received 1 glkg bwt DMSO in 1 I of lactated Ringer's solution i.v. immediately prior to reperfusion. There were no differences in the variables studied, and the authors concluded DMSO was not effective in preventing equine jejunal injury resulting from complete arterial occlusion followed by reperfusion (Arden etal. 1989). The results of that study were supported by a concurrent study by the same authors utilising a similar model, but evaluating the effect of DMSO utilising histological sampling of the jejunum. Again, DMSO was ineffective in preventing ischaemia-reperfusion injury (Arden etal. 1990).
机译：在第1部分（Schleining and Reinertson 2007）中研究了使用二甲亚砜作为局部抗炎剂以及关节内使用的证据。第2部分探讨了DMSO作为肠胃外抗炎药和药理载体的用途。肠胃外抗炎药：对DMSO清除氧衍生自由基的能力的观察已引起人们对防止胃肠道局部缺血后再灌注损伤的兴趣。该领域的许多研究都采用了低剂量小肠或大肠的全流量或完整的动脉和静脉闭塞模型。首次研究发表于1989年，包括18只小马，它们接受了1小时的空肠缺血治疗，然后再进行1小时的再灌注。 DMSO组中的小马在1 I.v.的乳酸林格氏液中接受了1 glkg bwt的DMSO。再灌注之前。在研究的变量中没有差异，作者得出结论，DMSO不能有效预防完全动脉闭塞后再灌注引起的马空肠损伤（Arden等，1989）。该研究的结果得到了同一作者使用相似模型的一项并行研究的支持，但是利用空肠的组织学采样评估了DMSO的效果。再次，DMSO在预防局部缺血-再灌注损伤方面无效（Arden等，1990）。

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