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首页> 外文期刊>Equine and Comparative Exercise Physiology >Effects of oral L-carnitine supplementation in racing Greyhounds.
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Effects of oral L-carnitine supplementation in racing Greyhounds.

机译：口服左旋肉碱补充剂在赛狗中的作用。

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L-Carnitine supplementation can stimulate erythropoiesis, reduce exercise-induced plasma lactate concentrations and decrease post-exercise muscle damage. Next to horses, Greyhounds represent the premier animal racing species and perform short-duration, very high-intensity exercise that has the potential to incur substantial muscle damage. Under resting and standard racing conditions (5/16 mile), we tested the novel hypotheses that L-carnitine supplementation in Greyhounds would: (1) elevate haematocrit at rest and immediately post-exercise; (2) reduce peak post-exercise plasma lactate; and (3) reduce indices of muscle damage (plasma creatine phosphokinase, CPK and aspartate aminotransferase, AST). Six conditioned Greyhounds (30.1+or-1.6 kg) underwent a randomized placebo-controlled crossover study to determine the effects of 6 weeks of L-carnitine supplementation (100 mg kg-1 of body weight/day) at rest and following a maximal speed 5/16 mile race. In accordance with our hypotheses, L-carnitine elevated resting and immediately post-race haematocrit (control, 60.1+or-1.7, L-carnitine, 63.6+or-1.7; P<0.05) and reduced peak post-race plasma CPK and AST concentrations (both P<0.05). Those dogs with the highest peak post-exercise plasma CPK concentrations under placebo conditions evidenced the greatest reduction with L-carnitine supplementation (r=0.99, P<0.01). However, contrary to our hypotheses, L-carnitine did not change peak post-exercise plasma lactate concentrations (control, 27.0+or-2.1, L-carnitine, 27.7+or-1.3; P>0.05). We conclude that L-carnitine supplementation increases the potential for oxygen transport and reduces plasma indicators of muscle damage, CPK and AST in racing Greyhounds.
机译：补充左旋肉碱可以刺激红细胞生成，降低运动引起的血浆乳酸浓度，并减少运动后的肌肉损伤。灵狮紧随马匹，代表着顶级的赛马品种，并进行短期，非常高强度的锻炼，有可能造成严重的肌肉损伤。在静止和标准比赛条件下（5/16英里），我们测试了灵缇补充左旋肉碱的新颖假设：（1）静止时提高血细胞比容并立即运动后; （2）减少运动后血浆乳酸峰; （3）降低肌肉损伤指数（血浆肌酸磷酸激酶，CPK和天冬氨酸转氨酶，AST）。六个条件灵狮（30.1+或-1.6千克）进行了一项随机安慰剂对照的交叉研究，以确定在静止和以最大速度进行6周L-肉碱补充（100 mg kg-1体重/天）的影响5/16英里竞赛。根据我们的假设，左旋肉碱可提高静息状态，并在赛后立即给予血细胞比容（对照组，60.1+或-1.7，左旋肉碱，63.6+或-1.7; P <0.05），并降低赛后血浆CPK和AST峰值浓度（均P <0.05）。在安慰剂条件下，运动后血浆CPK浓度峰值最高的那些狗表现出补充左旋肉碱的效果最大（r = 0.99，P <0.01）。然而，与我们的假设相反，左旋肉碱并未改变运动后血浆乳酸浓度的峰值（对照组，27.0+或-2.1，左旋肉碱，27.7+或-1.3; P> 0.05）。我们得出的结论是，补充左旋肉碱可增加氧气运输的潜力，并减少赛灵狮中肌肉损伤，CPK和AST的血浆指标。

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